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Statements

Subject Item
n2:RIV%2F00216208%3A11140%2F09%3A10103260%21RIV12-MSM-11140___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
We designed and synthesized 40 analogues of dofetilide and established structure-activity relationships for their interaction with hERG potassium channel. The data were derived with the aim to specify structural features that give rise to hERG toxicity. We designed and synthesized 40 analogues of dofetilide and established structure-activity relationships for their interaction with hERG potassium channel. The data were derived with the aim to specify structural features that give rise to hERG toxicity.
dcterms:title
Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues
skos:prefLabel
Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues
skos:notation
RIV/00216208:11140/09:10103260!RIV12-MSM-11140___
n3:aktivita
n16:V
n3:aktivity
V
n3:cisloPeriodika
10
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n8:4815998
n3:druhVysledku
n7:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
314387
n3:idVysledku
RIV/00216208:11140/09:10103260
n3:jazykVysledku
n18:eng
n3:klicovaSlova
structure-activity relationships; radioligand binding assays; ion channels; hERG; dofetilide; cardiotoxicity
n3:klicoveSlovo
n11:dofetilide n11:cardiotoxicity n11:structure-activity%20relationships n11:hERG n11:radioligand%20binding%20assays n11:ion%20channels
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[60D7C5DA1407]
n3:nazevZdroje
ChemMedChem
n3:obor
n17:ED
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n12:2009
n3:svazekPeriodika
4
n3:tvurceVysledku
Rook, Martin B. de Vries, Henk Vos, Marc A. Klaasse, Elisabeth Brussee, Johannes Nalos, Lukáš van der Heyden, Marcel A.G. Shagufta, Dong Guo IJzerman, Adriaan, P.
n3:wos
000270767900017
s:issn
1860-7179
s:numberOfPages
11
n9:doi
10.1002/cmdc.200900203
n6:organizacniJednotka
11140