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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F14%3A10293958%21RIV15-MSM-11130___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1093/humrep/deu130
dcterms:description
How has the interface between genetics and assisted reproduction technology (ART) evolved since 2005? The interface between ART and genetics has become more entwined as we increase our understanding about the genetics of infertility and we are able to perform more comprehensive genetic testing. In March 2005, a group of experts from the European Society of Human Genetics and European Society of Human Reproduction and Embryology met to discuss the interface between genetics and ART and published an extended background paper, recommendations and two Editorials. An interdisciplinary workshop was held, involving representatives of both professional societies and experts from the European Union Eurogentest2 Coordination Action Project. In March 2012, a group of experts from the European Society of Human Genetics, the European Society of Human Reproduction and Embryology and the EuroGentest2 Coordination Action Project met to discuss developments at the interface between clinical genetics and ART. As more genetic causes of reproductive failure are now recognized and an increasing number of patients undergo testing of their genome prior to conception, either in regular health care or in the context of direct-to-consumer testing, the need for genetic counselling and PGD may increase. Preimplantation genetic screening (PGS) thus far does not have evidence from RCTs to substantiate that the technique is both effective and efficient. Whole genome sequencing may create greater challenges both in the technological and interpretational domains, and requires further reflection about the ethics of genetic testing in ART and PGD/PGS. Diagnostic laboratories should be reporting their results according to internationally accepted accreditation standards (ISO 15189). Further studies are needed in order to address issues related to the impact of ART on epigenetic reprogramming of the early embryo. How has the interface between genetics and assisted reproduction technology (ART) evolved since 2005? The interface between ART and genetics has become more entwined as we increase our understanding about the genetics of infertility and we are able to perform more comprehensive genetic testing. In March 2005, a group of experts from the European Society of Human Genetics and European Society of Human Reproduction and Embryology met to discuss the interface between genetics and ART and published an extended background paper, recommendations and two Editorials. An interdisciplinary workshop was held, involving representatives of both professional societies and experts from the European Union Eurogentest2 Coordination Action Project. In March 2012, a group of experts from the European Society of Human Genetics, the European Society of Human Reproduction and Embryology and the EuroGentest2 Coordination Action Project met to discuss developments at the interface between clinical genetics and ART. As more genetic causes of reproductive failure are now recognized and an increasing number of patients undergo testing of their genome prior to conception, either in regular health care or in the context of direct-to-consumer testing, the need for genetic counselling and PGD may increase. Preimplantation genetic screening (PGS) thus far does not have evidence from RCTs to substantiate that the technique is both effective and efficient. Whole genome sequencing may create greater challenges both in the technological and interpretational domains, and requires further reflection about the ethics of genetic testing in ART and PGD/PGS. Diagnostic laboratories should be reporting their results according to internationally accepted accreditation standards (ISO 15189). Further studies are needed in order to address issues related to the impact of ART on epigenetic reprogramming of the early embryo.
dcterms:title
Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy
skos:prefLabel
Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy
skos:notation
RIV/00216208:11130/14:10293958!RIV15-MSM-11130___
n6:aktivita
n17:I
n6:aktivity
I
n6:cisloPeriodika
8
n6:dodaniDat
n11:2015
n6:domaciTvurceVysledku
n10:9104992
n6:druhVysledku
n19:J
n6:duvernostUdaju
n14:S
n6:entitaPredkladatele
n12:predkladatel
n6:idSjednocenehoVysledku
9425
n6:idVysledku
RIV/00216208:11130/14:10293958
n6:jazykVysledku
n18:eng
n6:klicovaSlova
IVF; reproductive genetics; European Society of Human Reproduction and Embryology; European Society of Human Genetics; assisted reproduction technology
n6:klicoveSlovo
n7:assisted%20reproduction%20technology n7:reproductive%20genetics n7:IVF n7:European%20Society%20of%20Human%20Genetics n7:European%20Society%20of%20Human%20Reproduction%20and%20Embryology
n6:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n6:kontrolniKodProRIV
[CAEBE656A672]
n6:nazevZdroje
Human Reproduction
n6:obor
n8:EB
n6:pocetDomacichTvurcuVysledku
1
n6:pocetTvurcuVysledku
22
n6:rokUplatneniVysledku
n11:2014
n6:svazekPeriodika
29
n6:tvurceVysledku
Gianaroli, Luca de Wert, Guido Liebaers, Inge Milachich, Tanya Borry, Pascal Skirton, Heather Viville, Stephane Spits, Claudia Macek, Milan Dondorp, Wybo J. Kaariainen, Helena Sermon, Karen Vermeesch, Joris Robert Veiga, Anna Harper, Joyce Morris, Michael Soini, Sirpa Sequeiros, Jorge Shenfield, Francoise Geraedts, Joep Cornel, Martina C. Harton, Gary
n6:wos
000340071000002
s:issn
0268-1161
s:numberOfPages
10
n15:doi
10.1093/humrep/deu130
n4:organizacniJednotka
11130