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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F14%3A10293070%21RIV15-MSM-11130___
rdf:type
n15:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.5507/bp.2012.106
dcterms:description
Background. The aim of this study was to assess retinal toxicity in a rabbit model after carboplatin delivered as repeated transcorneal intravitreal injection, in order to determine the highest possible safe dose for use in human retinoblastoma %22seeding%22 tumor chemotherapy. Methods and Results. We used six albino rabbits in an in vivo experiment and injected 0.008 mg of carboplatin intra-vitreally (iv) 4 times at two-week intervals. 0.08 mL saline was injected into the left eye. We recorded electroretinograms (ERGs) before the first carboplatin injection and after the fourth injection. Platinum concentration was measured 1 h after the fifth additional injection. We found reduced dark-adapted b-wave amplitudes and, light-adapted b-wave and a-wave amplitudes. The differences between right and left eyes was significant but we found no histopathologic retinal changes. Conclusions. 0.008 mg of carboplatin is probably the highest possible safe dose for the treatment of retinoblastoma patients. Questionable is direct extrapolation of retinal toxicity from the rabbit eye model to the human eye. Background. The aim of this study was to assess retinal toxicity in a rabbit model after carboplatin delivered as repeated transcorneal intravitreal injection, in order to determine the highest possible safe dose for use in human retinoblastoma %22seeding%22 tumor chemotherapy. Methods and Results. We used six albino rabbits in an in vivo experiment and injected 0.008 mg of carboplatin intra-vitreally (iv) 4 times at two-week intervals. 0.08 mL saline was injected into the left eye. We recorded electroretinograms (ERGs) before the first carboplatin injection and after the fourth injection. Platinum concentration was measured 1 h after the fifth additional injection. We found reduced dark-adapted b-wave amplitudes and, light-adapted b-wave and a-wave amplitudes. The differences between right and left eyes was significant but we found no histopathologic retinal changes. Conclusions. 0.008 mg of carboplatin is probably the highest possible safe dose for the treatment of retinoblastoma patients. Questionable is direct extrapolation of retinal toxicity from the rabbit eye model to the human eye.
dcterms:title
Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes
skos:prefLabel
Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes
skos:notation
RIV/00216208:11130/14:10293070!RIV15-MSM-11130___
n3:aktivita
n13:I
n3:aktivity
I
n3:cisloPeriodika
4
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n6:9506683 n6:3250709 n6:5070341 n6:4981480 n6:2310465 n6:9965122 n6:3082830 n6:3778924
n3:druhVysledku
n10:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
42555
n3:idVysledku
RIV/00216208:11130/14:10293070
n3:jazykVysledku
n16:eng
n3:klicovaSlova
retinoblastoma; rabbit; local treatment; intravitreal seeding; electroretinogram; carboplatin concentration
n3:klicoveSlovo
n4:intravitreal%20seeding n4:rabbit n4:carboplatin%20concentration n4:local%20treatment n4:retinoblastoma n4:electroretinogram
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[8FC010D82822]
n3:nazevZdroje
Biomedical Papers
n3:obor
n14:FD
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
158
n3:tvurceVysledku
Mališ, Josef Lestak, Jan Kodetová, Daniela Pochop, Pavel Uhlík, Jiří Kukačka, Jiří Darsová, Denisa Klapková, Eva Vajner, Luděk
n3:wos
000347173200009
s:issn
1213-8118
s:numberOfPages
5
n17:doi
10.5507/bp.2012.106
n9:organizacniJednotka
11130