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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F14%3A10293064%21RIV15-MSM-11130___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1186/s13028-014-0072-0
dcterms:description
Background: Hypoxia results in an imbalance between oxygen supply and oxygen consumption. This study utilized microdialysis to monitor changes in the energy-related metabolites lactate, pyruvate and glucose in rat muscle before, during and after 30 minutes of transient global hypoxia. Hypoxia was induced in anaesthetised rats by reducing inspired oxygen to 6% O-2 in nitrogen. Results: Basal values for lactate, the lactate/pyruvate ratio and glucose were 0.72 +/- 0.04 mmol/l, 10.03 +/- 1.16 and 3.55 +/- 0.19 mmol/l (n = 10), respectively. Significant increases in lactate and the lactate/pyruvate ratio were found in the muscle after the induction of hypoxia. Maximum values of 2.26 +/- 0.37 mmol/l for lactate were reached during early reperfusion, while the lactate/pyruvate ratio reached maximum values of 35.84 +/- 7.81 at the end of hypoxia. Following recovery to ventilation with air, extracellular lactate levels and the lactate/pyruvate ratio returned to control levels within 30-40 minutes. Extracellular glucose levels showed no significant difference between hypoxia and control experiments. Conclusions: In our study, the complete post-hypoxic recovery of metabolite levels suggests that metabolic enzymes of the skeletal muscle and their related cellular components may be able to tolerate severe hypoxic periods without prolonged damage. The consumption of glucose in the muscle in relation to its delivery seems to be unaffected. Background: Hypoxia results in an imbalance between oxygen supply and oxygen consumption. This study utilized microdialysis to monitor changes in the energy-related metabolites lactate, pyruvate and glucose in rat muscle before, during and after 30 minutes of transient global hypoxia. Hypoxia was induced in anaesthetised rats by reducing inspired oxygen to 6% O-2 in nitrogen. Results: Basal values for lactate, the lactate/pyruvate ratio and glucose were 0.72 +/- 0.04 mmol/l, 10.03 +/- 1.16 and 3.55 +/- 0.19 mmol/l (n = 10), respectively. Significant increases in lactate and the lactate/pyruvate ratio were found in the muscle after the induction of hypoxia. Maximum values of 2.26 +/- 0.37 mmol/l for lactate were reached during early reperfusion, while the lactate/pyruvate ratio reached maximum values of 35.84 +/- 7.81 at the end of hypoxia. Following recovery to ventilation with air, extracellular lactate levels and the lactate/pyruvate ratio returned to control levels within 30-40 minutes. Extracellular glucose levels showed no significant difference between hypoxia and control experiments. Conclusions: In our study, the complete post-hypoxic recovery of metabolite levels suggests that metabolic enzymes of the skeletal muscle and their related cellular components may be able to tolerate severe hypoxic periods without prolonged damage. The consumption of glucose in the muscle in relation to its delivery seems to be unaffected.
dcterms:title
Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia
skos:prefLabel
Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia
skos:notation
RIV/00216208:11130/14:10293064!RIV15-MSM-11130___
n3:aktivita
n14:I n14:P
n3:aktivity
I, P(1M0538), P(GA309/09/1597), P(LC554)
n3:cisloPeriodika
neuveden
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
n12:8356319 n12:6738109
n3:druhVysledku
n11:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
22552
n3:idVysledku
RIV/00216208:11130/14:10293064
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Metabolism; Glucose; Lactate; Recovery; Muscle; Microdialysis; Hypoxia
n3:klicoveSlovo
n9:Muscle n9:Lactate n9:Hypoxia n9:Metabolism n9:Microdialysis n9:Glucose n9:Recovery
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[2B38E2CF6221]
n3:nazevZdroje
Acta Veterinaria Scandinavica
n3:obor
n18:FH
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n5:LC554 n5:GA309%2F09%2F1597 n5:1M0538
n3:rokUplatneniVysledku
n16:2014
n3:svazekPeriodika
56
n3:tvurceVysledku
Syková, Eva Homola, Aleš Rossaint, Rolf Zoremba, Norbert
n3:wos
000344889000001
s:issn
0044-605X
s:numberOfPages
5
n15:doi
10.1186/s13028-014-0072-0
n7:organizacniJednotka
11130