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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F14%3A10293018%21RIV15-MSM-11130___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
OBJECTIVES: To evaluate the significance of plasma adrenomedullin and calcitonin gene-related peptide (CGRP) concentration in patients with Type 2 diabetes mellitus who are treated for hypertension and dyslipidemia. METHOD: Plasma adrenomedullin and CGRP concentration, transthoracal echocardiography and ABPM were evaluated in 82 patients with Type 2 diabetes mellitus and 41 control subjects with no previous cardiovascular disease. All the subjects had casual blood pressure =140/90 mmHg or received antihypertensive medication, were treated by statin if LDL cholesterol was }= 3mmol/L, by fibrates if triacylglyceroles }= 2 mmol/L. RESULTS: The mean age was 61 +/- 6 in patients with diabetes mellitus and 61 +/- 5 years in control subjects (p=0.9). Plasma CGRP was 3.0 +/- 1.8 in patients with diabetes mellitus and 2.3 +/- 1.0 ng/ml in control subjects (p=0.09). Plasma adrenomedullin was 2.2 +/- 0.9 in patients with diabetes mellitus and 2.8 +/- 1.1 ng/ml in control subjects (p=0.01). In patients with diabetes mellitus mass index of the left ventricle was significantly higher and the parameters of diastolic function were more deteriorated. Plasma adrenomedullin and CGRP correlated significantly negatively with serum creatinine and positively with mean 24 hours arterial blood pressure in patients with diabetes mellitus but not in control subjects. Plasma adrenomedullin concentration in patients with diabetes mellitus treated for hypertension was significantly reduced. CONCLUSION: Despite concentration plasma adrenomedullin and CGRP modulation by cardioprotective treatment both neuropeptides remained involved in regulation of hemodynamic and metabolic parameters in patients with Type 2 diabetes mellitus. The low plasma of adrenomedullin in patients with Type 2 diabetic may be marker of the efficient intervention on cardiovascular risk factors. OBJECTIVES: To evaluate the significance of plasma adrenomedullin and calcitonin gene-related peptide (CGRP) concentration in patients with Type 2 diabetes mellitus who are treated for hypertension and dyslipidemia. METHOD: Plasma adrenomedullin and CGRP concentration, transthoracal echocardiography and ABPM were evaluated in 82 patients with Type 2 diabetes mellitus and 41 control subjects with no previous cardiovascular disease. All the subjects had casual blood pressure =140/90 mmHg or received antihypertensive medication, were treated by statin if LDL cholesterol was }= 3mmol/L, by fibrates if triacylglyceroles }= 2 mmol/L. RESULTS: The mean age was 61 +/- 6 in patients with diabetes mellitus and 61 +/- 5 years in control subjects (p=0.9). Plasma CGRP was 3.0 +/- 1.8 in patients with diabetes mellitus and 2.3 +/- 1.0 ng/ml in control subjects (p=0.09). Plasma adrenomedullin was 2.2 +/- 0.9 in patients with diabetes mellitus and 2.8 +/- 1.1 ng/ml in control subjects (p=0.01). In patients with diabetes mellitus mass index of the left ventricle was significantly higher and the parameters of diastolic function were more deteriorated. Plasma adrenomedullin and CGRP correlated significantly negatively with serum creatinine and positively with mean 24 hours arterial blood pressure in patients with diabetes mellitus but not in control subjects. Plasma adrenomedullin concentration in patients with diabetes mellitus treated for hypertension was significantly reduced. CONCLUSION: Despite concentration plasma adrenomedullin and CGRP modulation by cardioprotective treatment both neuropeptides remained involved in regulation of hemodynamic and metabolic parameters in patients with Type 2 diabetes mellitus. The low plasma of adrenomedullin in patients with Type 2 diabetic may be marker of the efficient intervention on cardiovascular risk factors.
dcterms:title
The significance of plasma adrenomedullin and calcitonin gene-related peptide concentration in patients with Type 2 diabetes mellitus who are treated for cardiovascular risk factors The significance of plasma adrenomedullin and calcitonin gene-related peptide concentration in patients with Type 2 diabetes mellitus who are treated for cardiovascular risk factors
skos:prefLabel
The significance of plasma adrenomedullin and calcitonin gene-related peptide concentration in patients with Type 2 diabetes mellitus who are treated for cardiovascular risk factors The significance of plasma adrenomedullin and calcitonin gene-related peptide concentration in patients with Type 2 diabetes mellitus who are treated for cardiovascular risk factors
skos:notation
RIV/00216208:11130/14:10293018!RIV15-MSM-11130___
n3:aktivita
n17:I
n3:aktivity
I
n3:cisloPeriodika
2
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n10:7466692 n10:7627742 n10:5592542 n10:6807720
n3:druhVysledku
n6:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
44815
n3:idVysledku
RIV/00216208:11130/14:10293018
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Type 2 diabetes mellitus; cardiovascular risk factors; cardiovascular prognosis; CGRP; adrenomedullin
n3:klicoveSlovo
n4:Type%202%20diabetes%20mellitus n4:cardiovascular%20prognosis n4:adrenomedullin n4:cardiovascular%20risk%20factors n4:CGRP
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[BB1F176A19D9]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n7:FB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
35
n3:tvurceVysledku
Bílek, Radovan Charvát, Jiří Havlín, Jan Šváb, Přemysl Zamrazil, Václav
n3:wos
000340153900012
s:issn
0172-780X
s:numberOfPages
5
n14:organizacniJednotka
11130