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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F14%3A10292833%21RIV15-MSM-11130___
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.3109/00365521.2013.867358
dcterms:description
Objective. Neurological complications of inflammatory bowel diseases (IBDs) are not rare but are under-diagnosed; some are probably immune-mediated. Several previous studies have suggested a higher incidence of demyelinating diseases such as multiple sclerosis in IBD patients. In this single-center, prospective, observational study, the authors focus on T2 focal white-matter lesions of the central nervous system on magnetic resonance imaging (MRI) in IBD patients that may be due to demyelination. Material and methods. A total of 70 patients with Crohn's disease were examined before beginning anti-TNF-alpha a therapy. These patients were treated with azathioprine, mesalazine or both. Patients were examined by a neurologist to detect possible signs of demyelinating disease, and patients underwent brain MRI (native T1, T2, and FLAIR sequences). Results. Thirty-seven patients (53%) exhibited abnormalities on neurological examination, and 26 patients (37%) displayed abnormalities on MRI. In seven cases, these MRI abnormalities (periventricular lesions) were suspected to be due to demyelination. Cerebral spinal fluid investigation (including polyclonal bands) was completely negative in five cases and was borderline in one case, and multiple sclerosis was confirmed in one case. Pathological MRI findings in 19 other patients were clinically nonsignificant; most were nonspecific sporadic lesions in white matter or mild atrophy. Conclusions. The results support previous data that the frequency of neurological findings in IBD patients is generally underestimated. With the extension of biological anti-TNF-alpha treatment for IBD, the possibility of a higher risk of developing multiple sclerosis should be considered. Objective. Neurological complications of inflammatory bowel diseases (IBDs) are not rare but are under-diagnosed; some are probably immune-mediated. Several previous studies have suggested a higher incidence of demyelinating diseases such as multiple sclerosis in IBD patients. In this single-center, prospective, observational study, the authors focus on T2 focal white-matter lesions of the central nervous system on magnetic resonance imaging (MRI) in IBD patients that may be due to demyelination. Material and methods. A total of 70 patients with Crohn's disease were examined before beginning anti-TNF-alpha a therapy. These patients were treated with azathioprine, mesalazine or both. Patients were examined by a neurologist to detect possible signs of demyelinating disease, and patients underwent brain MRI (native T1, T2, and FLAIR sequences). Results. Thirty-seven patients (53%) exhibited abnormalities on neurological examination, and 26 patients (37%) displayed abnormalities on MRI. In seven cases, these MRI abnormalities (periventricular lesions) were suspected to be due to demyelination. Cerebral spinal fluid investigation (including polyclonal bands) was completely negative in five cases and was borderline in one case, and multiple sclerosis was confirmed in one case. Pathological MRI findings in 19 other patients were clinically nonsignificant; most were nonspecific sporadic lesions in white matter or mild atrophy. Conclusions. The results support previous data that the frequency of neurological findings in IBD patients is generally underestimated. With the extension of biological anti-TNF-alpha treatment for IBD, the possibility of a higher risk of developing multiple sclerosis should be considered.
dcterms:title
Crohn's disease: Is there a place for neurological screening? Crohn's disease: Is there a place for neurological screening?
skos:prefLabel
Crohn's disease: Is there a place for neurological screening? Crohn's disease: Is there a place for neurological screening?
skos:notation
RIV/00216208:11130/14:10292833!RIV15-MSM-11130___
n3:aktivita
n18:I
n3:aktivity
I
n3:cisloPeriodika
2
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n6:5371236 n6:5302102 n6:9146156 n6:7017391 n6:1333089
n3:druhVysledku
n17:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
9229
n3:idVysledku
RIV/00216208:11130/14:10292833
n3:jazykVysledku
n7:eng
n3:klicovaSlova
multiple sclerosis; inflammatory bowel diseases; demyelinating diseases; Crohn's disease
n3:klicoveSlovo
n5:demyelinating%20diseases n5:Crohn%27s%20disease n5:inflammatory%20bowel%20diseases n5:multiple%20sclerosis
n3:kodStatuVydavatele
NO - Norské království
n3:kontrolniKodProRIV
[D801AE213428]
n3:nazevZdroje
Scandinavian Journal of Gastroenterology
n3:obor
n19:FB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
49
n3:tvurceVysledku
Šťovíček, Jan Hlava, Štěpán Lišková, Petra Lisý, Jiří Keil, Radan
n3:wos
000329874800006
s:issn
0036-5521
s:numberOfPages
4
n14:doi
10.3109/00365521.2013.867358
n11:organizacniJednotka
11130