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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F14%3A10292810%21RIV15-MSM-11130___
rdf:type
n15:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1039/c3mt00132f
dcterms:description
Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic polymorphisms in a clinical context. In recent years, common MT polymorphisms were identified and associated with, particularly, western lifestyle diseases such as cancer, complications of atherosclerosis, and type 2 diabetes mellitus along with related complications. This review summarizes all evidence regarding MT polymorphisms of major human MTs (MT1, MT2, MT3 and MT4), their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies. Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic polymorphisms in a clinical context. In recent years, common MT polymorphisms were identified and associated with, particularly, western lifestyle diseases such as cancer, complications of atherosclerosis, and type 2 diabetes mellitus along with related complications. This review summarizes all evidence regarding MT polymorphisms of major human MTs (MT1, MT2, MT3 and MT4), their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies.
dcterms:title
Metallothionein polymorphisms in pathological processes Metallothionein polymorphisms in pathological processes
skos:prefLabel
Metallothionein polymorphisms in pathological processes Metallothionein polymorphisms in pathological processes
skos:notation
RIV/00216208:11130/14:10292810!RIV15-MSM-11130___
n5:aktivita
n18:I
n5:aktivity
I
n5:cisloPeriodika
1
n5:dodaniDat
n13:2015
n5:domaciTvurceVysledku
n8:9974687
n5:druhVysledku
n19:J
n5:duvernostUdaju
n7:S
n5:entitaPredkladatele
n10:predkladatel
n5:idSjednocenehoVysledku
28568
n5:idVysledku
RIV/00216208:11130/14:10292810
n5:jazykVysledku
n17:eng
n5:klicovaSlova
transcription factor; mammalian metallothionein; iia gene; gene-expression; oxidative stress; central-nervous-system; prostate-specific antigen; amyotrophic-lateral-sclerosis; single-nucleotide polymorphisms; metal-responsive elements
n5:klicoveSlovo
n6:amyotrophic-lateral-sclerosis n6:transcription%20factor n6:metal-responsive%20elements n6:gene-expression n6:prostate-specific%20antigen n6:iia%20gene n6:central-nervous-system n6:oxidative%20stress n6:mammalian%20metallothionein n6:single-nucleotide%20polymorphisms
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[581D8A986772]
n5:nazevZdroje
Metallomics : integrated biometal science
n5:obor
n9:FD
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
9
n5:rokUplatneniVysledku
n13:2014
n5:svazekPeriodika
6
n5:tvurceVysledku
Babula, Petr Podlaha, Ondrej Masarik, Michal Eckschlager, Tomáš Raudenska, Martina Kizekb, Rene Adam, Vojtěch Sztalmachova, Marketa Gumulec, Jaromír
n5:wos
000328891100004
s:issn
1756-5901
s:numberOfPages
14
n11:doi
10.1039/c3mt00132f
n4:organizacniJednotka
11130