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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F14%3A10288559%21RIV15-MSM-11130___
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1155/2014/303929
dcterms:description
Background. Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC). Patients with tumors of viral etiology have a lower recurrence rate and better prognosis. OPSCC is linked to an alteration in the immune system. Only a limited number of studies have correlated both the immunological parameters and HPV status with patient prognosis. The aim of this study was to determine whether HPV infection and the immunological status influence patient prognosis individually or in concurrence. Material and Methods. Sixty patients with oral and oropharyngeal carcinomas were enrolled. They were divided into HPV-positive and HPV-negative groups based on the expression of HPV 16 E6 mRNA. Basic lymphocyte subpopulations were determined in the peripheral blood by means of flow cytometry. Results. Significantly better disease-specific survival (DSS) was observed in patients with HPV-positive tumors. Nodal status, tumor grade, recurrence, and CD8+/Tregs ratio were identified as factors influencing DSS. A higher level of Tregs and a lower ratio of CD8/Tregs influenced overall survival (OS) independently of HPV status and age. Patients with HPV-positive tumors and high levels of Tregs survived significantly better than patients from the other groups. Conclusion. Better survival is associated with HPV positivity and elevated Tregs levels. Our data suggest that HPV infection and Tregs do not influence patient prognosis in concurrence. Background. Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC). Patients with tumors of viral etiology have a lower recurrence rate and better prognosis. OPSCC is linked to an alteration in the immune system. Only a limited number of studies have correlated both the immunological parameters and HPV status with patient prognosis. The aim of this study was to determine whether HPV infection and the immunological status influence patient prognosis individually or in concurrence. Material and Methods. Sixty patients with oral and oropharyngeal carcinomas were enrolled. They were divided into HPV-positive and HPV-negative groups based on the expression of HPV 16 E6 mRNA. Basic lymphocyte subpopulations were determined in the peripheral blood by means of flow cytometry. Results. Significantly better disease-specific survival (DSS) was observed in patients with HPV-positive tumors. Nodal status, tumor grade, recurrence, and CD8+/Tregs ratio were identified as factors influencing DSS. A higher level of Tregs and a lower ratio of CD8/Tregs influenced overall survival (OS) independently of HPV status and age. Patients with HPV-positive tumors and high levels of Tregs survived significantly better than patients from the other groups. Conclusion. Better survival is associated with HPV positivity and elevated Tregs levels. Our data suggest that HPV infection and Tregs do not influence patient prognosis in concurrence.
dcterms:title
High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV- Positive Oral and Oropharyngeal Squamous Cell Carcinomas High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV- Positive Oral and Oropharyngeal Squamous Cell Carcinomas
skos:prefLabel
High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV- Positive Oral and Oropharyngeal Squamous Cell Carcinomas High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV- Positive Oral and Oropharyngeal Squamous Cell Carcinomas
skos:notation
RIV/00216208:11130/14:10288559!RIV15-MSM-11130___
n3:aktivita
n5:P n5:I
n3:aktivity
I, P(GAP304/12/2244), P(NT12483)
n3:cisloPeriodika
April
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n13:9974687 n13:3386929
n3:druhVysledku
n20:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
19066
n3:idVysledku
RIV/00216208:11130/14:10288559
n3:jazykVysledku
n16:eng
n3:klicovaSlova
prevalence; expression; head; cervical-cancer; peripheral-blood; nk cells; neck-cancer; human-papillomavirus; tumor-infiltrating lymphocytes; regulatory t-cells
n3:klicoveSlovo
n11:prevalence n11:neck-cancer n11:head n11:cervical-cancer n11:nk%20cells n11:regulatory%20t-cells n11:expression n11:human-papillomavirus n11:peripheral-blood n11:tumor-infiltrating%20lymphocytes
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[2A7846382F87]
n3:nazevZdroje
BioMed Research International
n3:obor
n4:FF
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
11
n3:projekt
n14:GAP304%2F12%2F2244 n14:NT12483
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
2014
n3:tvurceVysledku
Rotnáglová, Eliška Říhová, B. Bouček, Jan Eckschlager, Tomáš Procházka, B. Grega, Marek Lukešová, Eva Klozar, Jan Tachezy, R. Salakova, M. Košľabová, Eva
n3:wos
000335233200001
s:issn
2314-6133
s:numberOfPages
11
n9:doi
10.1155/2014/303929
n19:organizacniJednotka
11130