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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F14%3A10284199%21RIV15-MSM-11130___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://www.prolekare.cz/linkout/50423
dcterms:description
Our present study was aimed to investigate time-profile kinetics of interleukins, vascular endothelial growth factor (VEGF) in acute inflammatory response following traumatic brain injury, and the influence of activated microglial cells in patients who developed severe space occupying lesion (SOL) of secondary traumatic brain injury. Interleukins IL-6, monocyte chemo attractant protein (MCP-1), and VEGF had a significant different time-profile kinetics (p<0.05) in patient with, and without expansive traumatic brain contusions (SOL). The serum VEGF was significantly higher in trauma patients with uncomplicated brain contusions, and lower in patients with SOL. The patients with septic complications developed the sudden increase of TNF alpha and IL-8 within the first 72 hours. Our data suggested PSGL and CD68 immunopositivity of microglial cells in both focal and diffuse TBI, predominantly in perivascular space correlated with telolysosome formation in cytoplasma. Polymorphism of PAI-1, MTHFR, eNOS, VEGF, and Apo E genes in TBI were in patients with SOL were bound to show up leucocyte plugging in capillaries. Our present study was aimed to investigate time-profile kinetics of interleukins, vascular endothelial growth factor (VEGF) in acute inflammatory response following traumatic brain injury, and the influence of activated microglial cells in patients who developed severe space occupying lesion (SOL) of secondary traumatic brain injury. Interleukins IL-6, monocyte chemo attractant protein (MCP-1), and VEGF had a significant different time-profile kinetics (p<0.05) in patient with, and without expansive traumatic brain contusions (SOL). The serum VEGF was significantly higher in trauma patients with uncomplicated brain contusions, and lower in patients with SOL. The patients with septic complications developed the sudden increase of TNF alpha and IL-8 within the first 72 hours. Our data suggested PSGL and CD68 immunopositivity of microglial cells in both focal and diffuse TBI, predominantly in perivascular space correlated with telolysosome formation in cytoplasma. Polymorphism of PAI-1, MTHFR, eNOS, VEGF, and Apo E genes in TBI were in patients with SOL were bound to show up leucocyte plugging in capillaries.
dcterms:title
Pathomorphology of inflammatory response following traumatic brain injury, serum values of interleukins, and gene polymorphisms Pathomorphology of inflammatory response following traumatic brain injury, serum values of interleukins, and gene polymorphisms
skos:prefLabel
Pathomorphology of inflammatory response following traumatic brain injury, serum values of interleukins, and gene polymorphisms Pathomorphology of inflammatory response following traumatic brain injury, serum values of interleukins, and gene polymorphisms
skos:notation
RIV/00216208:11130/14:10284199!RIV15-MSM-11130___
n3:aktivita
n8:I
n3:aktivity
I
n3:cisloPeriodika
4
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n4:2220253 n4:7328486
n3:druhVysledku
n16:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
35916
n3:idVysledku
RIV/00216208:11130/14:10284199
n3:jazykVysledku
n11:eng
n3:klicovaSlova
gene polymorphisms; monocyte chemoattractant protein; vascular endothelial growth factor; interleukins; microglial cells; acute inflammatory response; traumatic brain injury
n3:klicoveSlovo
n6:vascular%20endothelial%20growth%20factor n6:monocyte%20chemoattractant%20protein n6:interleukins n6:gene%20polymorphisms n6:traumatic%20brain%20injury n6:microglial%20cells n6:acute%20inflammatory%20response
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[A9DCC0A2C14E]
n3:nazevZdroje
Česko-slovenská patologie a Soudní lékařství
n3:obor
n18:FP
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
59
n3:tvurceVysledku
Strejc, Přemysl Zima, Tomáš Vajtr, David Samal, Filip Benada, Oldřich Staněk, Libor Průša, Richard Springer, Drahomíra Beran, Michal
s:issn
1210-7875
s:numberOfPages
8
n14:organizacniJednotka
11130