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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F13%3A10210500%21RIV14-MSM-11130___
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://www.fluidsbarrierscns.com/content/10/1/30
dcterms:description
BACKGROUND: Chemokines and cytokines in cerebrospinal fluid (CSF) and serum have been extensively studied in adults with neuroborreliosis (NB), whereas there are limited data about the pediatric population. In adults, T helper type 1 (Th1) and Th17-related cytokines were observed during acute NB. In children, the Th2 response is thought to moderate the disease course. The aim of this study was to determine the chemokine-cytokine profile in children with acute NB displaying Borrelia-related peripheral facial nerve palsy (PFNP). METHODS: Luminex multiple bead technology was used for the detection of twelve cytokines and chemokines in the CSF and serum of three groups: 1) children with Borrelia-related PFNP (BPFNP); 2) children with non-borrelial %22idiopathic%22 PFNP (NIPFNP); and 3) age-related controls. RESULTS: In BPFNP, cytokines-chemokines related to a non-specific pro-inflammatory activity and specific Th1/Th17 responses were detected in CSF, and elevated IL-7 and IL-10 levels were observed in serum and CSF compared to NIPFNP and to controls. In NIPFNP, CSF findings were similar to controls; however, higher levels of IL-7 and MCP-1 were observed in serum. Higher IL-8, IL-15 and MCP-1 levels were detected in CSF compared to serum in all groups. MCP-1 and IL-8 levels in CSF were strikingly higher in BPFNP compared to the other two groups, while IL-15 levels in CSF showed no difference. In addition, in controls, increased IL-4 level was found in CSF compared to serum. CONCLUSION: The chemokine-cytokine profile in the CSF of children with acute NB was similar to previous studies in adults. Our data suggests that higher levels of IL-4, IL-15 and MCP-1 levels in CSF compared to serum in controls might represent a potentially protective cytokine milieu in the CNS compartment. BACKGROUND: Chemokines and cytokines in cerebrospinal fluid (CSF) and serum have been extensively studied in adults with neuroborreliosis (NB), whereas there are limited data about the pediatric population. In adults, T helper type 1 (Th1) and Th17-related cytokines were observed during acute NB. In children, the Th2 response is thought to moderate the disease course. The aim of this study was to determine the chemokine-cytokine profile in children with acute NB displaying Borrelia-related peripheral facial nerve palsy (PFNP). METHODS: Luminex multiple bead technology was used for the detection of twelve cytokines and chemokines in the CSF and serum of three groups: 1) children with Borrelia-related PFNP (BPFNP); 2) children with non-borrelial %22idiopathic%22 PFNP (NIPFNP); and 3) age-related controls. RESULTS: In BPFNP, cytokines-chemokines related to a non-specific pro-inflammatory activity and specific Th1/Th17 responses were detected in CSF, and elevated IL-7 and IL-10 levels were observed in serum and CSF compared to NIPFNP and to controls. In NIPFNP, CSF findings were similar to controls; however, higher levels of IL-7 and MCP-1 were observed in serum. Higher IL-8, IL-15 and MCP-1 levels were detected in CSF compared to serum in all groups. MCP-1 and IL-8 levels in CSF were strikingly higher in BPFNP compared to the other two groups, while IL-15 levels in CSF showed no difference. In addition, in controls, increased IL-4 level was found in CSF compared to serum. CONCLUSION: The chemokine-cytokine profile in the CSF of children with acute NB was similar to previous studies in adults. Our data suggests that higher levels of IL-4, IL-15 and MCP-1 levels in CSF compared to serum in controls might represent a potentially protective cytokine milieu in the CNS compartment.
dcterms:title
Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy
skos:prefLabel
Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy
skos:notation
RIV/00216208:11130/13:10210500!RIV14-MSM-11130___
n8:predkladatel
n20:orjk%3A11130
n3:aktivita
n14:I
n3:aktivity
I
n3:cisloPeriodika
30
n3:dodaniDat
n10:2014
n3:domaciTvurceVysledku
n13:9187502 n13:2336227 n13:6100317
n3:druhVysledku
n15:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
111054
n3:idVysledku
RIV/00216208:11130/13:10210500
n3:jazykVysledku
n4:eng
n3:klicovaSlova
palsy; nerve; facial; Borrelia-related; with; children; fluid; cerebrospinal; spectrum; cytokine; Th2-related; but; Th17; Th1
n3:klicoveSlovo
n7:Th1 n7:nerve n7:Borrelia-related n7:cytokine n7:but n7:fluid n7:cerebrospinal n7:Th17 n7:spectrum n7:facial n7:with n7:Th2-related n7:palsy n7:children
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[26D4FD2BC3F7]
n3:nazevZdroje
Fluids and Barriers of the CNS
n3:obor
n9:FH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n10:2013
n3:svazekPeriodika
10
n3:tvurceVysledku
Komárek, Vladimír Kayserová, Jana Libá, Zuzana
s:issn
2045-8118
s:numberOfPages
6
n19:doi
10.1186/2045-8118-10-30
n18:organizacniJednotka
11130