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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F13%3A10209665%21RIV14-MZ0-11130___
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1113/jphysiol.2012.239590
dcterms:description
Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a hypersynchronous state. Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and dynamical evolution of synchronization. Desynchronization is often observed preceding seizures or during their early stages; in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination. In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization. Recent work has identified cell-type-specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non-local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non-firing neurons active in seizures. These recent advances have challenged long-established views and are leading to a more rigorous and realistic understanding of the pathophysiology of epilepsy. Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a hypersynchronous state. Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and dynamical evolution of synchronization. Desynchronization is often observed preceding seizures or during their early stages; in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination. In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization. Recent work has identified cell-type-specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non-local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non-firing neurons active in seizures. These recent advances have challenged long-established views and are leading to a more rigorous and realistic understanding of the pathophysiology of epilepsy.
dcterms:title
Synchronization and desynchronization in epilepsy: controversies and hypotheses Synchronization and desynchronization in epilepsy: controversies and hypotheses
skos:prefLabel
Synchronization and desynchronization in epilepsy: controversies and hypotheses Synchronization and desynchronization in epilepsy: controversies and hypotheses
skos:notation
RIV/00216208:11130/13:10209665!RIV14-MZ0-11130___
n9:predkladatel
n12:orjk%3A11130
n3:aktivita
n18:P n18:I
n3:aktivity
I, P(NT11460)
n3:cisloPeriodika
4
n3:dodaniDat
n16:2014
n3:domaciTvurceVysledku
n20:5798868
n3:druhVysledku
n19:J
n3:duvernostUdaju
n21:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
109370
n3:idVysledku
RIV/00216208:11130/13:10209665
n3:jazykVysledku
n14:eng
n3:klicovaSlova
focal epileptogenesis; phase synchronization; spatiotemporal dynamics; in-vitro; chaotic systems; neuronal-activity; fast ripples; seizure onset zone; temporal-lobe epilepsy; high-frequency oscillations
n3:klicoveSlovo
n4:phase%20synchronization n4:focal%20epileptogenesis n4:spatiotemporal%20dynamics n4:neuronal-activity n4:seizure%20onset%20zone n4:in-vitro n4:temporal-lobe%20epilepsy n4:high-frequency%20oscillations n4:fast%20ripples n4:chaotic%20systems
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[926C9858151F]
n3:nazevZdroje
Journal of Physiology
n3:obor
n5:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n11:NT11460
n3:rokUplatneniVysledku
n16:2013
n3:svazekPeriodika
591
n3:tvurceVysledku
Schevon, Catherine A. Jiruška, Přemysl de Curtis, Marco Schiff, Steven J. Jefferys, John G. R. Schindler, Kaspar
n3:wos
000315150000007
s:issn
0022-3751
s:numberOfPages
11
n13:doi
10.1113/jphysiol.2012.239590
n8:organizacniJednotka
11130