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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F13%3A10209656%21RIV14-MSM-11130___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.2217/NNM.12.140
dcterms:description
Platelet derivatives serve as an efficient source of natural growth factors. In the current study, alpha-granules were incorporated into coaxial nanofibers. Materials & methods: A nanofiber scaffold containing a-granules was prepared by coaxial electrospinning. The biological potential of the nanofiber scaffold was evaluated in chondrocyte and mesenchymal stem cell cultivation studies. Additionally, the concentration of TGF-beta 1 was determined. Results: Microscopy studies showed that intact alpha-granules were incorporated into the coaxial nanofibers. The cultivation tests showed that the novel scaffold stimulated viability and extracellular matrix production of chondrocytes and mesenchymal stem cells. In addition, the concentration of growth factors necessary for the induction of cell proliferation significantly decreased. Conclusion: The system preserved alpha-granule bioactivity and stimulated cell viability and chondrogenic differentiation of mesenchymal stem cells. Core/shell nanofibers incorporating a-granules are a promising system for tissue engineering, particularly cartilage engineering. Platelet derivatives serve as an efficient source of natural growth factors. In the current study, alpha-granules were incorporated into coaxial nanofibers. Materials & methods: A nanofiber scaffold containing a-granules was prepared by coaxial electrospinning. The biological potential of the nanofiber scaffold was evaluated in chondrocyte and mesenchymal stem cell cultivation studies. Additionally, the concentration of TGF-beta 1 was determined. Results: Microscopy studies showed that intact alpha-granules were incorporated into the coaxial nanofibers. The cultivation tests showed that the novel scaffold stimulated viability and extracellular matrix production of chondrocytes and mesenchymal stem cells. In addition, the concentration of growth factors necessary for the induction of cell proliferation significantly decreased. Conclusion: The system preserved alpha-granule bioactivity and stimulated cell viability and chondrogenic differentiation of mesenchymal stem cells. Core/shell nanofibers incorporating a-granules are a promising system for tissue engineering, particularly cartilage engineering.
dcterms:title
Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use
skos:prefLabel
Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use
skos:notation
RIV/00216208:11130/13:10209656!RIV14-MSM-11130___
n10:predkladatel
n22:orjk%3A11130
n5:aktivita
n18:S n18:P n18:Z
n5:aktivity
P(GAP304/10/1307), P(ME10145), S, Z(AV0Z50390512), Z(AV0Z50390703)
n5:cisloPeriodika
7
n5:dodaniDat
n9:2014
n5:domaciTvurceVysledku
n6:3458830 n6:4313534 n6:2664275 n6:6178685 n6:2710862 n6:1304992
n5:druhVysledku
n14:J
n5:duvernostUdaju
n21:S
n5:entitaPredkladatele
n20:predkladatel
n5:idSjednocenehoVysledku
111118
n5:idVysledku
RIV/00216208:11130/13:10209656
n5:jazykVysledku
n11:eng
n5:klicovaSlova
mesenchymal stem cell; growth factor; encapsulation; electrospinning; core/shell material; chondrocyte; alpha-granules
n5:klicoveSlovo
n7:electrospinning n7:chondrocyte n7:core%2Fshell%20material n7:encapsulation n7:mesenchymal%20stem%20cell n7:growth%20factor n7:alpha-granules
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[F0B22F6415C1]
n5:nazevZdroje
Nanomedicine
n5:obor
n16:BO
n5:pocetDomacichTvurcuVysledku
6
n5:pocetTvurcuVysledku
8
n5:projekt
n19:ME10145 n19:GAP304%2F10%2F1307
n5:rokUplatneniVysledku
n9:2013
n5:svazekPeriodika
8
n5:tvurceVysledku
Jakubová, Radka Buzgo, Matej Míčková, Andrea Lukas, David Amler, Evžen Rampichová, Michala Prosecká, Eva Kochova, Petra
n5:wos
000320853500017
n5:zamer
n12:AV0Z50390703 n12:AV0Z50390512
s:issn
1743-5889
s:numberOfPages
18
n17:doi
10.2217/NNM.12.140
n15:organizacniJednotka
11130