This HTML5 document contains 73 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n9http://localhost/temp/predkladatel/
n6http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n18http://linked.opendata.cz/resource/domain/vavai/subjekt/
n12http://linked.opendata.cz/ontology/domain/vavai/
n13http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11130%2F13%3A10196703%21RIV14-MSM-11130___/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n8http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n10http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n20http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n19http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n14http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F13%3A10196703%21RIV14-MSM-11130___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1038/leu.2013.135
dcterms:description
Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (similar to 90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements. Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (similar to 90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements.
dcterms:title
The MLL recombinome of acute leukemias in 2013 The MLL recombinome of acute leukemias in 2013
skos:prefLabel
The MLL recombinome of acute leukemias in 2013 The MLL recombinome of acute leukemias in 2013
skos:notation
RIV/00216208:11130/13:10196703!RIV14-MSM-11130___
n12:predkladatel
n18:orjk%3A11130
n3:aktivita
n19:I
n3:aktivity
I
n3:cisloPeriodika
11
n3:dodaniDat
n14:2014
n3:domaciTvurceVysledku
n6:1071718 n6:7396104
n3:druhVysledku
n4:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
88621
n3:idVysledku
RIV/00216208:11130/13:10196703
n3:jazykVysledku
n20:eng
n3:klicovaSlova
AML; ALL; acute leukemia; translocation partner genes; chromosomal translocations; MLL
n3:klicoveSlovo
n10:acute%20leukemia n10:chromosomal%20translocations n10:AML n10:translocation%20partner%20genes n10:ALL n10:MLL
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[497C1DA3B27E]
n3:nazevZdroje
Leukemia
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
87
n3:rokUplatneniVysledku
n14:2013
n3:svazekPeriodika
27
n3:tvurceVysledku
Silva, M. L. M. Trka, Jan Zuna, Jan Fechina, L. Cave, H. Delabesse, E. Burmeister, T. Meyer, C. Park, T. S. Oh, S. H. Groeger, D. Mass-Malo, K. Juvonen, V. Kustanovich, A. Emerenciano, M. Tsaur, G. Clappier, E. Hofmann, J. Macintyre, E. Aleinikova, O. Harris, M. H. van Dongen, J. J. M. De Braekeleer, M. van der Velden, V. H. J. Binato, R. De Braekeleer, E. Villarese, P. Renneville, A. de Oliveira, M. Pombo Lund-Aho, T.
n3:wos
000326882500007
s:issn
0887-6924
s:numberOfPages
12
n8:doi
10.1038/leu.2013.135
n9:organizacniJednotka
11130