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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F13%3A10196666%21RIV14-MZ0-11130___
rdf:type
n14:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.3233/JAD-122431
dcterms:description
Several recent studies have indicated that white matter is affected in Alzheimer's disease (AD). Diffusion tensor imaging is a tool by which the white matter microstructure can be examined in vivo, and might offer a possibility for the identification of the pattern of white matter disintegration in AD. In the current analysis, we made use of a novel model-free analysis approach of linked independent component analysis to identify a motif of diffusion parameter alterations exemplifying AD. Analysis of the diffusion data of 16 AD patients and 17 age-matched healthy subjects revealed six independent components, two of which demonstrated differences between the patients and controls. Component #0 was dominated by axial diffusivity, but significant alterations in fractional anisotropy and mean and radial diffusivity were also detected. Alterations were found in regions of crossing of major white matter pathways, such as forceps, corona radiata, and superior longitudinal fascicle, as well as medio-temporal white matter. These results lend support to the coexistence of white matter disintegration of the late myelinating associating fibers and wallerian degeneration-related disintegration, in accordance with the retrogenesis and wallerian degeneration hypothesis. Several recent studies have indicated that white matter is affected in Alzheimer's disease (AD). Diffusion tensor imaging is a tool by which the white matter microstructure can be examined in vivo, and might offer a possibility for the identification of the pattern of white matter disintegration in AD. In the current analysis, we made use of a novel model-free analysis approach of linked independent component analysis to identify a motif of diffusion parameter alterations exemplifying AD. Analysis of the diffusion data of 16 AD patients and 17 age-matched healthy subjects revealed six independent components, two of which demonstrated differences between the patients and controls. Component #0 was dominated by axial diffusivity, but significant alterations in fractional anisotropy and mean and radial diffusivity were also detected. Alterations were found in regions of crossing of major white matter pathways, such as forceps, corona radiata, and superior longitudinal fascicle, as well as medio-temporal white matter. These results lend support to the coexistence of white matter disintegration of the late myelinating associating fibers and wallerian degeneration-related disintegration, in accordance with the retrogenesis and wallerian degeneration hypothesis.
dcterms:title
The Pattern of Diffusion Parameter Changes in Alzheimer's Disease, Identified by Means of Linked Independent Component Analysis The Pattern of Diffusion Parameter Changes in Alzheimer's Disease, Identified by Means of Linked Independent Component Analysis
skos:prefLabel
The Pattern of Diffusion Parameter Changes in Alzheimer's Disease, Identified by Means of Linked Independent Component Analysis The Pattern of Diffusion Parameter Changes in Alzheimer's Disease, Identified by Means of Linked Independent Component Analysis
skos:notation
RIV/00216208:11130/13:10196666!RIV14-MZ0-11130___
n14:predkladatel
n15:orjk%3A11130
n3:aktivita
n20:I n20:P
n3:aktivity
I, P(ED1.100/02/0123), P(NS10331)
n3:cisloPeriodika
1
n3:dodaniDat
n16:2014
n3:domaciTvurceVysledku
n11:5878276
n3:druhVysledku
n5:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
95542
n3:idVysledku
RIV/00216208:11130/13:10196666
n3:jazykVysledku
n19:eng
n3:klicovaSlova
magnetic resonance imaging; linked independent component analysis; diffusion tensor imaging; Alzheimer's disease
n3:klicoveSlovo
n6:magnetic%20resonance%20imaging n6:Alzheimer%27s%20disease n6:linked%20independent%20component%20analysis n6:diffusion%20tensor%20imaging
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[361FB035CE11]
n3:nazevZdroje
Journal of Alzheimer's Disease
n3:obor
n8:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:projekt
n17:ED1.100%2F02%2F0123 n17:NS10331
n3:rokUplatneniVysledku
n16:2013
n3:svazekPeriodika
36
n3:tvurceVysledku
Kincses, Zsigmond Tamas Hort, Jakub Vecsei, Laszlo Toth, Eszter Szabo, Nikoletta Csete, Gergo Horinek, Daniel Štěpán-Buksakowska, Irena
n3:wos
000320030200011
s:issn
1387-2877
s:numberOfPages
10
n21:doi
10.3233/JAD-122431
n18:organizacniJednotka
11130