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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F13%3A10193840%21RIV14-MZ0-11130___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1002/ijc.27759
dcterms:description
The type of immune cells that are present within the tumor microenvironment can play a crucial role in the survival of patients. However, little is known about the dynamics of the tumor-infiltrating immune cells during disease progression. We studied the immune cells that infiltrated the tumor tissues of ovarian cancer patients at different stages of disease. The early stages of development of ovarian carcinomas were characterized by a strong Th17 immune response, whereas in stage II patients, recruitment of high numbers of Th1 cells was observed. In disseminated tumors (Stages III-IV), we detected a dominant population of Helios 1 activated regulatory T cells (Tregs) along with high numbers of monocytes/macrophages and myeloid dendritic cells (mDCs). Tumor-infiltrating Tregs had markedly lower expression of CCR4 than circulating Tregs, and the numbers of tumor-infiltrating Tregs significantly correlated with the levels of CCL22 in ovarian tumor cell culture supernatants, suggesting their recruitment via a CCR4/CCL22 interaction. CCL22 was mainly produced by tumor cells, monocytes/ macrophages and mDCs in the primary ovarian tumors, and its expression markedly increased in response to IFN gamma. Taken together, the specific recruitment of Tregs, probably triggered by inflammatory stimuli, leads to a significant immune suppression in the advanced stages of ovarian cancer. The type of immune cells that are present within the tumor microenvironment can play a crucial role in the survival of patients. However, little is known about the dynamics of the tumor-infiltrating immune cells during disease progression. We studied the immune cells that infiltrated the tumor tissues of ovarian cancer patients at different stages of disease. The early stages of development of ovarian carcinomas were characterized by a strong Th17 immune response, whereas in stage II patients, recruitment of high numbers of Th1 cells was observed. In disseminated tumors (Stages III-IV), we detected a dominant population of Helios 1 activated regulatory T cells (Tregs) along with high numbers of monocytes/macrophages and myeloid dendritic cells (mDCs). Tumor-infiltrating Tregs had markedly lower expression of CCR4 than circulating Tregs, and the numbers of tumor-infiltrating Tregs significantly correlated with the levels of CCL22 in ovarian tumor cell culture supernatants, suggesting their recruitment via a CCR4/CCL22 interaction. CCL22 was mainly produced by tumor cells, monocytes/ macrophages and mDCs in the primary ovarian tumors, and its expression markedly increased in response to IFN gamma. Taken together, the specific recruitment of Tregs, probably triggered by inflammatory stimuli, leads to a significant immune suppression in the advanced stages of ovarian cancer.
dcterms:title
Dynamics of T-cell infiltration during the course of ovarian cancer: The gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells Dynamics of T-cell infiltration during the course of ovarian cancer: The gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells
skos:prefLabel
Dynamics of T-cell infiltration during the course of ovarian cancer: The gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells Dynamics of T-cell infiltration during the course of ovarian cancer: The gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells
skos:notation
RIV/00216208:11130/13:10193840!RIV14-MZ0-11130___
n12:predkladatel
n13:orjk%3A11130
n3:aktivita
n15:Z n15:S n15:P
n3:aktivity
P(NT12402), S, Z(MSM0021620812)
n3:cisloPeriodika
5
n3:dodaniDat
n16:2014
n3:domaciTvurceVysledku
n10:6435467 n10:8086478 n10:7298471 n10:3746917 n10:2619229 n10:1645315 n10:1110047 n10:6146414 n10:1287362
n3:druhVysledku
n19:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
70977
n3:idVysledku
RIV/00216208:11130/13:10193840
n3:jazykVysledku
n18:eng
n3:klicovaSlova
recruitment; CCL22; Treg; Th17; epithelial ovarian cancer
n3:klicoveSlovo
n6:Th17 n6:Treg n6:epithelial%20ovarian%20cancer n6:CCL22 n6:recruitment
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[F0F6E466B637]
n3:nazevZdroje
International Journal of Cancer
n3:obor
n20:FD
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
10
n3:projekt
n9:NT12402
n3:rokUplatneniVysledku
n16:2013
n3:svazekPeriodika
132
n3:tvurceVysledku
Fialová, Anna Fučíková, Jitka Kocián, Petr Hromádková, Hana Rob, Lukáš Sojka, Luděk Partlová, Simona Špíšek, Radek Bartůňková, Jiřina Brtnický, Tomáš
n3:wos
000314071300009
n3:zamer
n4:MSM0021620812
s:issn
0020-7136
s:numberOfPages
10
n21:doi
10.1002/ijc.27759
n7:organizacniJednotka
11130