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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F13%3A10135344%21RIV14-GA0-11130___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous reports indicate that MT protects cells from exposure to oxidants and electrophiles, which react readily with sulfhydryl groups. Moreover, MT plays a key role in regulation of zinc levels and distribution in the intracellular space. The connections between zinc, MT and cancer are highlighted. Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous reports indicate that MT protects cells from exposure to oxidants and electrophiles, which react readily with sulfhydryl groups. Moreover, MT plays a key role in regulation of zinc levels and distribution in the intracellular space. The connections between zinc, MT and cancer are highlighted.
dcterms:title
The Role of Metallothionein in Oxidative Stress The Role of Metallothionein in Oxidative Stress
skos:prefLabel
The Role of Metallothionein in Oxidative Stress The Role of Metallothionein in Oxidative Stress
skos:notation
RIV/00216208:11130/13:10135344!RIV14-GA0-11130___
n13:predkladatel
n16:orjk%3A11130
n3:aktivita
n7:I n7:P
n3:aktivity
I, P(ED1.1.00/02.0068), P(GAP301/10/0356)
n3:cisloPeriodika
3
n3:dodaniDat
n5:2014
n3:domaciTvurceVysledku
n15:9974687
n3:druhVysledku
n12:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
103340
n3:idVysledku
RIV/00216208:11130/13:10135344
n3:jazykVysledku
n18:eng
n3:klicovaSlova
cancer; transcription factor; zinc; cellular oxidative stress; free radicals; metallothionein
n3:klicoveSlovo
n4:free%20radicals n4:transcription%20factor n4:cellular%20oxidative%20stress n4:cancer n4:zinc n4:metallothionein
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[C2B5E745519C]
n3:nazevZdroje
International Journal of Molecular Sciences [online]
n3:obor
n20:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:projekt
n10:ED1.1.00%2F02.0068 n10:GAP301%2F10%2F0356
n3:rokUplatneniVysledku
n5:2013
n3:svazekPeriodika
14
n3:tvurceVysledku
Eckschlager, Tomáš Kizek, René Gumulec, Jaromír Masařík, Michal Zítka, Ondřej Nejdl, Lukáš Ruttkay-Nedecký, Branislav Stiborová, Marie Adam, Vojtěch
n3:wos
000316609800090
s:issn
1422-0067
s:numberOfPages
23
n11:doi
10.3390/ijms14036044
n9:organizacniJednotka
11130