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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F12%3A8273%21RIV13-MSM-11130___
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1111/dth.12006
dcterms:description
Vitiligo is a depigmenting disorder stemming from melanocyte loss or dysfunction. It has a complex, multifaceted etiology. We constructed a vitiligo road map, consisting of basic science, clinical, and treatment components, in order to better portray our current understanding of vitiligo pathogenesis and reflect upon novel biomarkers and therapeutic targets for future research. The melanocyte map elaborates on the molecular processes and intracellular signaling pathways initiated by various external autocrine/paracrine factors in representing normal melanocyte homeostatic functions modulating its viability, proliferation, differentiation, dendricity, migration, and melanogenic processes. This vitiligo map identifies known inducers/triggers of vitiligo onset and progression that cultivate a microenvironment for melanocyte disappearance, real or functional. This map describes the molecular mechanisms of currently utilized clinical and experimental treatments of vitiligo that facilitate repigmentation. Vitiligo is a depigmenting disorder stemming from melanocyte loss or dysfunction. It has a complex, multifaceted etiology. We constructed a vitiligo road map, consisting of basic science, clinical, and treatment components, in order to better portray our current understanding of vitiligo pathogenesis and reflect upon novel biomarkers and therapeutic targets for future research. The melanocyte map elaborates on the molecular processes and intracellular signaling pathways initiated by various external autocrine/paracrine factors in representing normal melanocyte homeostatic functions modulating its viability, proliferation, differentiation, dendricity, migration, and melanogenic processes. This vitiligo map identifies known inducers/triggers of vitiligo onset and progression that cultivate a microenvironment for melanocyte disappearance, real or functional. This map describes the molecular mechanisms of currently utilized clinical and experimental treatments of vitiligo that facilitate repigmentation.
dcterms:title
Vitiligo road map Vitiligo road map
skos:prefLabel
Vitiligo road map Vitiligo road map
skos:notation
RIV/00216208:11130/12:8273!RIV13-MSM-11130___
n13:predkladatel
n14:orjk%3A11130
n4:aktivita
n10:I
n4:aktivity
I
n4:cisloPeriodika
1
n4:dodaniDat
n7:2013
n4:domaciTvurceVysledku
n17:5791278
n4:druhVysledku
n12:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
177621
n4:idVysledku
RIV/00216208:11130/12:8273
n4:jazykVysledku
n15:eng
n4:klicovaSlova
biomarkers; vitiligo; melanocyte; pigmentation; melanogenesis; hepatocyte growth-factor; melanocyte-stimulating hormone; non-segmental vitiligo; narrow-band-uvb; extracellular-matrix components; psoralen plus ultraviolet; factor scatter factor; c-kit ligand; nitric-oxide; t-cells
n4:klicoveSlovo
n5:melanocyte n5:pigmentation n5:factor%20scatter%20factor n5:nitric-oxide n5:t-cells n5:narrow-band-uvb n5:biomarkers n5:non-segmental%20vitiligo n5:c-kit%20ligand n5:psoralen%20plus%20ultraviolet n5:extracellular-matrix%20components n5:melanogenesis n5:melanocyte-stimulating%20hormone n5:hepatocyte%20growth-factor n5:vitiligo
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[C20A77EBA27F]
n4:nazevZdroje
Dermatologic Therapy
n4:obor
n8:FO
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
5
n4:rokUplatneniVysledku
n7:2012
n4:svazekPeriodika
25
n4:tvurceVysledku
Hercogová, Jana Lotti, T. M. Schwartz, R. A. Valle, Y. Lee, BW
n4:wos
000312304200007
s:issn
1396-0296
s:numberOfPages
13
n16:organizacniJednotka
11130