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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F11%3A7571%21RIV12-MZ0-11130___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://actavet.vfu.cz/pdf/201180040385.pdf
dcterms:description
The aim of this study was to characterize the extent of toxicity of focal carboplatin administration and to identify the dose limiting toxicity in rabbit eyes depending on administered concentrations.The dose limiting toxicity was reached in group II after periocular injection of 30 mg of carboplatin and in group III after intravitreal injection of 0.05 mg of carboplatin. No systemic toxicity was observed in any group.Focal carboplatin administration may decrease systemic exposure to this cytotoxic drug in the retinoblastoma treatment. This moreover suggests that focal carboplatin administration is a promising approach and challenge for advanced retinoblastoma chemotherapy. The aim of this study was to characterize the extent of toxicity of focal carboplatin administration and to identify the dose limiting toxicity in rabbit eyes depending on administered concentrations.The dose limiting toxicity was reached in group II after periocular injection of 30 mg of carboplatin and in group III after intravitreal injection of 0.05 mg of carboplatin. No systemic toxicity was observed in any group.Focal carboplatin administration may decrease systemic exposure to this cytotoxic drug in the retinoblastoma treatment. This moreover suggests that focal carboplatin administration is a promising approach and challenge for advanced retinoblastoma chemotherapy.
dcterms:title
Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes
skos:prefLabel
Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes
skos:notation
RIV/00216208:11130/11:7571!RIV12-MZ0-11130___
n13:predkladatel
n15:orjk%3A11130
n3:aktivita
n6:I n6:P
n3:aktivity
I, P(NR9532)
n3:cisloPeriodika
4
n3:dodaniDat
n16:2012
n3:domaciTvurceVysledku
n4:9965122 n4:3082830 n4:9506683 n4:5032768 n4:3778924 n4:4981480 n4:3250709
n3:druhVysledku
n10:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
198407
n3:idVysledku
RIV/00216208:11130/11:7571
n3:jazykVysledku
n18:eng
n3:klicovaSlova
carboplatin chemotherapy; New Zealand White Rabbits; intravitreal treatment; periocular toxicity; retinoblastoma
n3:klicoveSlovo
n8:carboplatin%20chemotherapy n8:intravitreal%20treatment n8:periocular%20toxicity n8:retinoblastoma n8:New%20Zealand%20White%20Rabbits
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[1B5603271B63]
n3:nazevZdroje
Acta Veterinaria Brno
n3:obor
n19:FF
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n7:NR9532
n3:rokUplatneniVysledku
n16:2011
n3:svazekPeriodika
80
n3:tvurceVysledku
Uhlík, Jiří Darsová, Denisa Kukačka, Jiří Pochop, Pavel Dotřelová, Dagmar Vajner, Luděk Kodetová, Daniela
n3:wos
000301811400011
s:issn
0001-7213
s:numberOfPages
6
n17:organizacniJednotka
11130