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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F11%3A7055%21RIV12-MSM-11130___
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pubmed/21674832
dcterms:description
Aim To evaluate Y-chromosomal diversity of the Moravian Valachs of the Czech Republic and compare them with a Czech population sample and other samples from Central and South-Eastern Europe, and to evaluate the effects of genetic isolation and sampling. Methods The first sample set of the Valachs consisted of 94 unrelated male donors from the Valach region in northeastern Czech Republic border-area. The second sample set of the Valachs consisted of 79 men who originated from 7 paternal lineages defined by surname. No close relatives were sampled. The third sample set consisted of 273 unrelated men from the whole of the Czech Republic and was used for comparison, as well as published data for other 27 populations. The total number of samples was 3244. Y-short tandem repeat (STR) markers were typed by standard methods using PowerPlex (R) Y System (Promega) and Yfiler (R) Amplification Kit (Applied Biosystems) kits. Y-chromosomal haplogroups were estimated from the haplotype information. Haplotype diversity and other intra-and inter-population statistics were computed. Results The Moravian Valachs showed a lower genetic variability of Y-STR markers than other Central European populations, resembling more to the isolated Balkan populations (Aromuns, Csango, Bulgarian, and Macedonian Roma) than the surrounding populations (Czechs, Slovaks, Poles, Saxons). We illustrated the effect of sampling on Valach paternal lineages, which includes reduction of discrimination capacity and variability inside Y-chromosomal haplogroups. Valach modal haplotype belongs to R1a haplogroup and it was not detected in the Czech population. Conclusion The Moravian Valachs display strong substructure and isolation in their Y chromosomal markers. They represent a unique Central European population model for population genetics. Aim To evaluate Y-chromosomal diversity of the Moravian Valachs of the Czech Republic and compare them with a Czech population sample and other samples from Central and South-Eastern Europe, and to evaluate the effects of genetic isolation and sampling. Methods The first sample set of the Valachs consisted of 94 unrelated male donors from the Valach region in northeastern Czech Republic border-area. The second sample set of the Valachs consisted of 79 men who originated from 7 paternal lineages defined by surname. No close relatives were sampled. The third sample set consisted of 273 unrelated men from the whole of the Czech Republic and was used for comparison, as well as published data for other 27 populations. The total number of samples was 3244. Y-short tandem repeat (STR) markers were typed by standard methods using PowerPlex (R) Y System (Promega) and Yfiler (R) Amplification Kit (Applied Biosystems) kits. Y-chromosomal haplogroups were estimated from the haplotype information. Haplotype diversity and other intra-and inter-population statistics were computed. Results The Moravian Valachs showed a lower genetic variability of Y-STR markers than other Central European populations, resembling more to the isolated Balkan populations (Aromuns, Csango, Bulgarian, and Macedonian Roma) than the surrounding populations (Czechs, Slovaks, Poles, Saxons). We illustrated the effect of sampling on Valach paternal lineages, which includes reduction of discrimination capacity and variability inside Y-chromosomal haplogroups. Valach modal haplotype belongs to R1a haplogroup and it was not detected in the Czech population. Conclusion The Moravian Valachs display strong substructure and isolation in their Y chromosomal markers. They represent a unique Central European population model for population genetics.
dcterms:title
Y-chromosomal diversity of the Valachs from the Czech Republic: model for isolated population in Central Europe Y-chromosomal diversity of the Valachs from the Czech Republic: model for isolated population in Central Europe
skos:prefLabel
Y-chromosomal diversity of the Valachs from the Czech Republic: model for isolated population in Central Europe Y-chromosomal diversity of the Valachs from the Czech Republic: model for isolated population in Central Europe
skos:notation
RIV/00216208:11130/11:7055!RIV12-MSM-11130___
n9:predkladatel
n13:orjk%3A11130
n3:aktivita
n7:I n7:S n7:Z
n3:aktivity
I, S, Z(MSM0021620843)
n3:cisloPeriodika
3
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n16:7638981
n3:druhVysledku
n20:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
242036
n3:idVysledku
RIV/00216208:11130/11:7055
n3:jazykVysledku
n14:eng
n3:klicovaSlova
str haplotypes; croatian population; reference database; gene flow; loci; perspective; networks; lineages; heritage; sample
n3:klicoveSlovo
n4:str%20haplotypes n4:heritage n4:sample n4:lineages n4:gene%20flow n4:loci n4:networks n4:reference%20database n4:perspective n4:croatian%20population
n3:kodStatuVydavatele
HR - Chorvatská republika
n3:kontrolniKodProRIV
[9A35CA850E1A]
n3:nazevZdroje
Croatian Medical Journal
n3:obor
n18:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
52
n3:tvurceVysledku
Vaněk, Daniel Vancata, V. Stenzl, V. Ehler, E.
n3:wos
000292873600013
n3:zamer
n11:MSM0021620843
s:issn
0353-9504
s:numberOfPages
10
n10:organizacniJednotka
11130