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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F10%3A6341%21RIV11-MZ0-11130___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Aim: The aim of our study was to analyse cytokine composition of human milk and its relationship to the development of eosinophilic colitis (EC). Methods: Cytokines were measured by ELISA method in breast milk of 20 mothers of infants who developed EC and 20 controls. Results: We found significantly higher concentrations of interferon-gamma (IFN-gamma) (Th1 cytokine) in breast milk received by EC infants compared to controls (p = 0.0004). In contrary, IL-18 (Th1-inducing cytokine) was significantly higher in breast milk received by healthy infants comparing to EC infants (p = 0.001). Regulatory cytokine transforming growth factor beta1 (TGF-beta1) showed higher concentrations in breast milk received by healthy infants, although the difference from EC group was not significant (p = 0.072). Conclusion: The results of our study showed that infants with EC were receiving breast milk with a possibly risky cytokine pattern indicating cytokine imbalance, impaired immunoregulation and the early Th1 shift. Aim: The aim of our study was to analyse cytokine composition of human milk and its relationship to the development of eosinophilic colitis (EC). Methods: Cytokines were measured by ELISA method in breast milk of 20 mothers of infants who developed EC and 20 controls. Results: We found significantly higher concentrations of interferon-gamma (IFN-gamma) (Th1 cytokine) in breast milk received by EC infants compared to controls (p = 0.0004). In contrary, IL-18 (Th1-inducing cytokine) was significantly higher in breast milk received by healthy infants comparing to EC infants (p = 0.001). Regulatory cytokine transforming growth factor beta1 (TGF-beta1) showed higher concentrations in breast milk received by healthy infants, although the difference from EC group was not significant (p = 0.072). Conclusion: The results of our study showed that infants with EC were receiving breast milk with a possibly risky cytokine pattern indicating cytokine imbalance, impaired immunoregulation and the early Th1 shift.
dcterms:title
Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis? Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis?
skos:prefLabel
Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis? Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis?
skos:notation
RIV/00216208:11130/10:6341!RIV11-MZ0-11130___
n4:aktivita
n16:P n16:I
n4:aktivity
I, P(NR8310)
n4:cisloPeriodika
11
n4:dodaniDat
n11:2011
n4:domaciTvurceVysledku
n6:7276990 n6:2433435 n6:1407910 n6:2214512 n6:1682822 n6:4866649
n4:druhVysledku
n13:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
264983
n4:idVysledku
RIV/00216208:11130/10:6341
n4:jazykVysledku
n10:eng
n4:klicovaSlova
breast milk; cytokine; eosinophilic colitis
n4:klicoveSlovo
n8:eosinophilic%20colitis n8:breast%20milk n8:cytokine
n4:kodStatuVydavatele
NO - Norské království
n4:kontrolniKodProRIV
[E166DB261A10]
n4:nazevZdroje
Acta Paediatrica
n4:obor
n12:FG
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
6
n4:projekt
n9:NR8310
n4:rokUplatneniVysledku
n11:2010
n4:svazekPeriodika
99
n4:tvurceVysledku
Štechová, Kateřina Durilová, Marianna Nevoral, Jiří Šťavíková, Vendula Ulmannová, Tereza Petruželková, Lenka
n4:wos
000282641600013
s:issn
0803-5253
s:numberOfPages
5
n18:organizacniJednotka
11130