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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F10%3A6255%21RIV11-GA0-11130___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with laminin-derived Ac-CGGASIKVAVS-OH peptide sequences have been developed to construct scaffolds that promote cell adhesion and neural differentiation. Superporous scaffolds significantly increased the number of attached mesenchymal stem cells and their growth area on the hydrogel surface in the absence and in the presence of serum in the culture medium. Additionally, the Ac-CGGASIKVAVS-OH peptide supported the attachment, proliferation, differentiation and process spreading of human fetal neural stem cells during the first two weeks of expansion and contributed to the formation of a high percentage of more mature neural cells after four weeks of expansion. Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with laminin-derived Ac-CGGASIKVAVS-OH peptide sequences have been developed to construct scaffolds that promote cell adhesion and neural differentiation. Superporous scaffolds significantly increased the number of attached mesenchymal stem cells and their growth area on the hydrogel surface in the absence and in the presence of serum in the culture medium. Additionally, the Ac-CGGASIKVAVS-OH peptide supported the attachment, proliferation, differentiation and process spreading of human fetal neural stem cells during the first two weeks of expansion and contributed to the formation of a high percentage of more mature neural cells after four weeks of expansion.
dcterms:title
The use of superporous Ac-CGGASIKVAVS-OH-modified PHEMA scaffolds to promote cell adhesion and the differentiation of human fetal neural precursors The use of superporous Ac-CGGASIKVAVS-OH-modified PHEMA scaffolds to promote cell adhesion and the differentiation of human fetal neural precursors
skos:prefLabel
The use of superporous Ac-CGGASIKVAVS-OH-modified PHEMA scaffolds to promote cell adhesion and the differentiation of human fetal neural precursors The use of superporous Ac-CGGASIKVAVS-OH-modified PHEMA scaffolds to promote cell adhesion and the differentiation of human fetal neural precursors
skos:notation
RIV/00216208:11130/10:6255!RIV11-GA0-11130___
n4:aktivita
n16:S n16:P n16:Z
n4:aktivity
P(1M0538), P(GD309/08/H079), P(IAA500390902), P(LC554), S, Z(AV0Z40500505), Z(AV0Z50390703)
n4:cisloPeriodika
23
n4:dodaniDat
n8:2011
n4:domaciTvurceVysledku
n11:6738109 n11:3244792 n11:6220533 n11:8640874
n4:druhVysledku
n17:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
294724
n4:idVysledku
RIV/00216208:11130/10:6255
n4:jazykVysledku
n15:eng
n4:klicovaSlova
Cell adhesion; Laminin; Mesenchymal stem cell; Neural cell; PolyHEMA; hydrogels; peptide; degradation; attachment; outgrowth; ikvav
n4:klicoveSlovo
n7:peptide n7:attachment n7:PolyHEMA n7:ikvav n7:Laminin n7:outgrowth n7:hydrogels n7:Neural%20cell n7:degradation n7:Mesenchymal%20stem%20cell n7:Cell%20adhesion
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[174F77B45DC4]
n4:nazevZdroje
Biomaterials
n4:obor
n6:FP
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
8
n4:projekt
n9:GD309%2F08%2FH079 n9:LC554 n9:1M0538 n9:IAA500390902
n4:rokUplatneniVysledku
n8:2010
n4:svazekPeriodika
31
n4:tvurceVysledku
Kubinova, S. Syková, Eva Prokš, Zdeněk Price, J. Horak, D. Kozubenko, Nataliya Cocks, G. Vaněček, Václav
n4:wos
000279719600007
n4:zamer
n5:AV0Z50390703 n5:AV0Z40500505
s:issn
0142-9612
s:numberOfPages
10
n14:organizacniJednotka
11130