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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F10%3A6058%21RIV11-GA0-11130___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Olfactory ensheathing glia (OEG) and mesenchymal stromal cells (MSC) have been investigated as promising candidates for spinal cord repair. In this study, the effect of the transplantation of OEG and/or MSC on behavioral, electrophysiologic and histologic outcomes after SCI was studied. Both OEG and MSC could foster locomotor function by sparing the spinal cord, but their combined advantages provide no added benefit to SCI therapy. We speculate that to maximize the advantageous effects of co-transplantation, direct implantation of OEG into the spinal cord lesion accompanied by intravenous injection of MSC might be more efficacious approach to the co-transplantation of OEG and MSC. Olfactory ensheathing glia (OEG) and mesenchymal stromal cells (MSC) have been investigated as promising candidates for spinal cord repair. In this study, the effect of the transplantation of OEG and/or MSC on behavioral, electrophysiologic and histologic outcomes after SCI was studied. Both OEG and MSC could foster locomotor function by sparing the spinal cord, but their combined advantages provide no added benefit to SCI therapy. We speculate that to maximize the advantageous effects of co-transplantation, direct implantation of OEG into the spinal cord lesion accompanied by intravenous injection of MSC might be more efficacious approach to the co-transplantation of OEG and MSC.
dcterms:title
Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat
skos:prefLabel
Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat
skos:notation
RIV/00216208:11130/10:6058!RIV11-GA0-11130___
n3:aktivita
n15:Z n15:P
n3:aktivity
P(1A8697), P(1M0538), P(GA309/06/1246), P(IAA500390902), P(LC554), Z(AV0Z50390703)
n3:cisloPeriodika
2
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n8:4798201 n8:6738109
n3:druhVysledku
n18:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
252241
n3:idVysledku
RIV/00216208:11130/10:6058
n3:jazykVysledku
n6:eng
n3:klicovaSlova
stem-cells; schwann-cells; in-vivo; cavity formation; lamina-propria; white-matter; migration; recovery; rho; regeneration
n3:klicoveSlovo
n4:recovery n4:regeneration n4:white-matter n4:rho n4:cavity%20formation n4:schwann-cells n4:stem-cells n4:lamina-propria n4:in-vivo n4:migration
n3:kodStatuVydavatele
NO - Norské království
n3:kontrolniKodProRIV
[623CFC2252AB]
n3:nazevZdroje
Cytotherapy
n3:obor
n10:FJ
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:projekt
n7:LC554 n7:IAA500390902 n7:1A8697 n7:1M0538 n7:GA309%2F06%2F1246
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
12
n3:tvurceVysledku
Arboleda, D. Ruzickova, K. Jendelová, Pavla Syková, Eva Amemori, T.
n3:wos
000275110600010
n3:zamer
n17:AV0Z50390703
s:issn
1465-3249
s:numberOfPages
14
n12:organizacniJednotka
11130