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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F10%3A10294188%21RIV15-MSM-11130___
rdf:type
n4:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.urolonc.2008.10.004
dcterms:description
Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with }= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families. Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc. Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with }= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families. Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc.
dcterms:title
The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred
skos:prefLabel
The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred
skos:notation
RIV/00216208:11130/10:10294188!RIV15-MSM-11130___
n3:aktivita
n13:I
n3:aktivity
I
n3:cisloPeriodika
5
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n9:5648823
n3:druhVysledku
n12:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
264558
n3:idVysledku
RIV/00216208:11130/10:10294188
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Clinicopathologic characteristics; Epidemiology; Familial; Testicular neoplasms
n3:klicoveSlovo
n11:Familial n11:Clinicopathologic%20characteristics n11:Epidemiology n11:Testicular%20neoplasms
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[C6275B14AE50]
n3:nazevZdroje
Urologic Oncology: Seminars and Original Investigations
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
33
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
28
n3:tvurceVysledku
Bodrogi, Istvan Richard, Stephane Heidenreich, Axel Albers, Peter Tucker, Kathy Phillips, Kelly-Anne Jewett, Michael A. S. Olah, Edith Mai, Phuong L. Stratton, Michael R. Tjulandin, Sergei A. Huddart, Robert Liubchenko, Ludmila Geczi, Lajos Guilford, Parry Heimdal, Ketil Daly, Peter A. Nathanson, Katherine L. Dudakia, Darshna Korde, Larissa Einhorn, Lawrence Fossa, Sophie D. Friedlander, Michael Stoll, Hans Bonaiti-Pellie, Catherine Daugaard, Gedske Lohynská, Radka Hogg, David Weber, Walter Easton, Douglas F.
n3:wos
000282542700007
s:issn
1078-1439
s:numberOfPages
8
n18:doi
10.1016/j.urolonc.2008.10.004
n19:organizacniJednotka
11130