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Statements

Subject Item
n2:RIV%2F00216208%3A11130%2F09%3A5423%21RIV10-MZ0-11130___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Allogeneic hematopoetic stem cell transplantation (HSCT) represents a unique opportunity to monitor the kinetics of reconstitution of dendritic cells (DCs) and their dynamics in distinct pathologies. We analyzed DCs reconstitution after myeloablative HSCT We separately analyzed patients with acute GVHD. DCs were monitored from the earliest phase of hematopoetic reconstitution until day + 365. Both myeloid DCs and plasmacytoid DCs appeared at earliest stages after engraftment and relative numbers within white blood cells compartment peaked between days 19-25 after HSCT Their proportion then gradually declined and absolute numbers of both DC subsets remained lower than in controls during the whole follow-up. Patients with acute GVHD had significantly tower numbers of circulating DCs. Decrease in DC counts preceded onset of clinical symptoms by at least 24 h and was independent of corticosteroids administration. This study reveals quantification of plasmacytoid and myeloid DCs as a potential biomarker fo Allogeneic hematopoetic stem cell transplantation (HSCT) represents a unique opportunity to monitor the kinetics of reconstitution of dendritic cells (DCs) and their dynamics in distinct pathologies. We analyzed DCs reconstitution after myeloablative HSCT We separately analyzed patients with acute GVHD. DCs were monitored from the earliest phase of hematopoetic reconstitution until day + 365. Both myeloid DCs and plasmacytoid DCs appeared at earliest stages after engraftment and relative numbers within white blood cells compartment peaked between days 19-25 after HSCT Their proportion then gradually declined and absolute numbers of both DC subsets remained lower than in controls during the whole follow-up. Patients with acute GVHD had significantly tower numbers of circulating DCs. Decrease in DC counts preceded onset of clinical symptoms by at least 24 h and was independent of corticosteroids administration. This study reveals quantification of plasmacytoid and myeloid DCs as a potential biomarker fo
dcterms:title
Kinetics of dendritic cells reconstitution and costimulatory molecules expression after myeloablative allogeneic haematopoetic stem cell transplantation: Implications for the development of acute graft-versus host disease Kinetics of dendritic cells reconstitution and costimulatory molecules expression after myeloablative allogeneic haematopoetic stem cell transplantation: Implications for the development of acute graft-versus host disease
skos:prefLabel
Kinetics of dendritic cells reconstitution and costimulatory molecules expression after myeloablative allogeneic haematopoetic stem cell transplantation: Implications for the development of acute graft-versus host disease Kinetics of dendritic cells reconstitution and costimulatory molecules expression after myeloablative allogeneic haematopoetic stem cell transplantation: Implications for the development of acute graft-versus host disease
skos:notation
RIV/00216208:11130/09:5423!RIV10-MZ0-11130___
n3:aktivita
n13:Z n13:P
n3:aktivity
P(GA310/08/0838), Z(MSM0021620812), Z(MZ0FNM2005)
n3:cisloPeriodika
1
n3:dodaniDat
n7:2010
n3:domaciTvurceVysledku
n6:2780089 n6:4977939 n6:9187502 n6:1287362 n6:7629419 n6:1110047 n6:1891871 n6:8646597 n6:6858775
n3:druhVysledku
n18:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
321748
n3:idVysledku
RIV/00216208:11130/09:5423
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Dendritic cell; Acute GVHD; Corticosteroids; BMT; HSCT; antigen-presenting cells; peripheral-blood; langerhans cells; steady-state; t-cells; in-vivo; differentiation; gvhd; generation; maturation
n3:klicoveSlovo
n4:peripheral-blood n4:HSCT n4:steady-state n4:differentiation n4:Acute%20GVHD n4:Dendritic%20cell n4:antigen-presenting%20cells n4:maturation n4:langerhans%20cells n4:BMT n4:t-cells n4:generation n4:gvhd n4:in-vivo n4:Corticosteroids
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E622FB3335B1]
n3:nazevZdroje
Clinical Immunology
n3:obor
n15:EC
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
9
n3:projekt
n14:GA310%2F08%2F0838
n3:rokUplatneniVysledku
n7:2009
n3:svazekPeriodika
131
n3:tvurceVysledku
Špíšek, Radek Budinský, Vít Kayserová, Jana Bartůňková, Jiřina Starý, Jan Formánková, Renata Kalina, Tomáš Horváth, Rudolf Sedláček, Petr
n3:wos
000264835000007
n3:zamer
n17:MZ0FNM2005 n17:MSM0021620812
s:issn
1521-6616
s:numberOfPages
10
n19:organizacniJednotka
11130