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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F15%3A43909408%21RIV15-MSM-11120___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Background: Neuroimaging changes in bipolar disorder (BD) may be secondary to the presence of certain clinical factors. Type 2 diabetes mellitus (T2DM) damages the brain and frequently co-occurs with BD. Studying patients with both T2DM and BD could help identify preventable risk factors for neuroimaging changes in BD. Methods: We used 1.5T magnetic resonance spectroscopy to measure prefrontal N-acetylaspartate (NAA), which is mainly localized in neurons, and total creatine (tCr), an energy metabolite, in 19 BD patients with insulin resistance/glucose intolerance (BD + IR/GI), 14 BD subjects with T2DM (BD + T2DM), 15 euglycemic BD participants, and 11 euglycemic, nonpsychiatric control. Results: The levels of NAA and tCr were lowest among BD + T2DM, intermediate in the BD + IR/GI, and highest among the euglycemic BD and control subjects (F3,55 = 4.57, p = .006; F3,55 = 2.92, p = .04, respectively). Even the BD + IR/GI subjects had lower NAA than the euglycemic participants (t43 = 2.13, p = .04). Total Cr was associated with NAA (β = .52, t56 = 5.57, p = .000001). Both NAA and tCr correlated with Global Assessment of Functioning scores (r46 = .28, p = .05; r46 = .48, p = .0004, respectively). Conclusions: T2DM, but also prediabetes, may be risk factors for prefrontal neurochemical alterations in BD. These changes were associated with poor psychosocial functioning and could indicate impaired energy metabolism. The findings emphasize the importance of improving diabetes care in BD and suggest potential options for treatment of neuroimaging alterations. Background: Neuroimaging changes in bipolar disorder (BD) may be secondary to the presence of certain clinical factors. Type 2 diabetes mellitus (T2DM) damages the brain and frequently co-occurs with BD. Studying patients with both T2DM and BD could help identify preventable risk factors for neuroimaging changes in BD. Methods: We used 1.5T magnetic resonance spectroscopy to measure prefrontal N-acetylaspartate (NAA), which is mainly localized in neurons, and total creatine (tCr), an energy metabolite, in 19 BD patients with insulin resistance/glucose intolerance (BD + IR/GI), 14 BD subjects with T2DM (BD + T2DM), 15 euglycemic BD participants, and 11 euglycemic, nonpsychiatric control. Results: The levels of NAA and tCr were lowest among BD + T2DM, intermediate in the BD + IR/GI, and highest among the euglycemic BD and control subjects (F3,55 = 4.57, p = .006; F3,55 = 2.92, p = .04, respectively). Even the BD + IR/GI subjects had lower NAA than the euglycemic participants (t43 = 2.13, p = .04). Total Cr was associated with NAA (β = .52, t56 = 5.57, p = .000001). Both NAA and tCr correlated with Global Assessment of Functioning scores (r46 = .28, p = .05; r46 = .48, p = .0004, respectively). Conclusions: T2DM, but also prediabetes, may be risk factors for prefrontal neurochemical alterations in BD. These changes were associated with poor psychosocial functioning and could indicate impaired energy metabolism. The findings emphasize the importance of improving diabetes care in BD and suggest potential options for treatment of neuroimaging alterations.
dcterms:title
Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders
skos:prefLabel
Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders
skos:notation
RIV/00216208:11120/15:43909408!RIV15-MSM-11120___
n3:aktivita
n5:V
n3:aktivity
V
n3:cisloPeriodika
3
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n15:8421382 n15:2224151
n3:druhVysledku
n16:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
479
n3:idVysledku
RIV/00216208:11120/15:43909408
n3:jazykVysledku
n12:eng
n3:klicovaSlova
type 2 diabetes mellitus; total creatine; prefrontal cortex; N-acetylaspartate; global assessment of functioning; bipolar disorder
n3:klicoveSlovo
n7:type%202%20diabetes%20mellitus n7:prefrontal%20cortex n7:bipolar%20disorder n7:global%20assessment%20of%20functioning n7:N-acetylaspartate n7:total%20creatine
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[30C582879433]
n3:nazevZdroje
Biological Psychiatry
n3:obor
n11:FH
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n13:2015
n3:svazekPeriodika
77
n3:tvurceVysledku
Hájek, Tomáš Alda, Martin
n3:wos
000346845500018
s:issn
0006-3223
s:numberOfPages
9
n18:doi
10.1016/j.biopsych.2013.11.007
n17:organizacniJednotka
11120