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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F15%3A43909391%21RIV15-MSM-11120___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Perinatal immune challenge leads to neurodevelopmental dysfunction, permanent immune dysregulation and abnormal behaviour, which have been shown to have translational validity to findings in human neuropsychiatric disorders (e.g. schizophrenia, mood and anxiety disorders, autism, Parkinson's disease and Alzheimer's disease). The aim of this animal study was to elucidate the influence of early immune stimulation triggered by systemic postnatal lipopolysaccharide administration on biochemical, histopathological and morphological measures, which may be relevant to the neurobiology of human psychopathology. In the present study of adult male Wistar rats we examined the brain and plasma levels of monoamines (dopamine, serotonin), their metabolites, the levels of the main excitatory and inhibitory neurotransmitters glutamate and Y-aminobutyric acid and the levels of tryptophan and its metabolites from the kynurenine catabolic pathway. Further, we focused on histopathological and morphological markers related to pathogenesis of brain diseases - glial cell activation, neurodegeneration, hippocampal volume reduction and dopaminergic synthesis in the substantia nigra. Our results show that early immune stimulation in adult animals alters the levels of neurotransmitters and their metabolites, activates the kynurenine pathway of tryptophan metabolism and leads to astrogliosis, hippocampal volume reduction and a decrease of tyrosine hydroxylase immunoreactivity in the substantia nigra. These findings support the crucial pathophysiological role of early immune stimulation in the above mentioned neuropsychiatric disorders. Perinatal immune challenge leads to neurodevelopmental dysfunction, permanent immune dysregulation and abnormal behaviour, which have been shown to have translational validity to findings in human neuropsychiatric disorders (e.g. schizophrenia, mood and anxiety disorders, autism, Parkinson's disease and Alzheimer's disease). The aim of this animal study was to elucidate the influence of early immune stimulation triggered by systemic postnatal lipopolysaccharide administration on biochemical, histopathological and morphological measures, which may be relevant to the neurobiology of human psychopathology. In the present study of adult male Wistar rats we examined the brain and plasma levels of monoamines (dopamine, serotonin), their metabolites, the levels of the main excitatory and inhibitory neurotransmitters glutamate and Y-aminobutyric acid and the levels of tryptophan and its metabolites from the kynurenine catabolic pathway. Further, we focused on histopathological and morphological markers related to pathogenesis of brain diseases - glial cell activation, neurodegeneration, hippocampal volume reduction and dopaminergic synthesis in the substantia nigra. Our results show that early immune stimulation in adult animals alters the levels of neurotransmitters and their metabolites, activates the kynurenine pathway of tryptophan metabolism and leads to astrogliosis, hippocampal volume reduction and a decrease of tyrosine hydroxylase immunoreactivity in the substantia nigra. These findings support the crucial pathophysiological role of early immune stimulation in the above mentioned neuropsychiatric disorders.
dcterms:title
Biochemical, Histopathological and Morphological Profiling of a Rat Model of Early Immune Stimulation: Relation to Psychopathology Biochemical, Histopathological and Morphological Profiling of a Rat Model of Early Immune Stimulation: Relation to Psychopathology
skos:prefLabel
Biochemical, Histopathological and Morphological Profiling of a Rat Model of Early Immune Stimulation: Relation to Psychopathology Biochemical, Histopathological and Morphological Profiling of a Rat Model of Early Immune Stimulation: Relation to Psychopathology
skos:notation
RIV/00216208:11120/15:43909391!RIV15-MSM-11120___
n3:aktivita
n16:S n16:I
n3:aktivity
I, S
n3:cisloPeriodika
1
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
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n3:druhVysledku
n15:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
46
n3:idVysledku
RIV/00216208:11120/15:43909391
n3:jazykVysledku
n18:eng
n3:klicovaSlova
schizophrenia; lipopolysaccharide; brain; later-life; quinolinic acid; plasma tryptophan; microglial activation; neonatal exposure; gamma-aminobutyric-acid; posttraumatic-stress-disorder
n3:klicoveSlovo
n7:quinolinic%20acid n7:posttraumatic-stress-disorder n7:microglial%20activation n7:neonatal%20exposure n7:schizophrenia n7:gamma-aminobutyric-acid n7:plasma%20tryptophan n7:brain n7:later-life n7:lipopolysaccharide
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[ED887E119AB7]
n3:nazevZdroje
PLoS One
n3:obor
n10:FH
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n8:2015
n3:svazekPeriodika
10
n3:tvurceVysledku
Tylš, Filip Kubešová, Anna Fujáková, Michaela Horáček, Jiří Páleníček, Tomáš
n3:wos
000348203500014
s:issn
1932-6203
s:numberOfPages
16
n5:doi
10.1371/journal.pone.0115439
n17:organizacniJednotka
11120