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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F15%3A43909167%21RIV15-MSM-11120___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Systemic sclerosis is a chronic, progressive disease with an extremely poor prognosis. The incidence of malignant tumors in patients with systemic sclerosis is increased when compared with that of the general population. In certain malignancies, systemic sclerosis presents as a paraneoplastic process. The symptoms of sclerosis in the organs of the head and neck often overlap with symptoms of malignant diseases, which may increase the difficulty of a differential diagnosis. Additionally, the presence of sclerosis may complicate standard examination procedures, due to poor access to the oral cavity and oropharynx. When considering treatment options, it is important to evaluate the surgical and oncological risks to soft tissues of the head and neck with regard to both diseases, as well as the relatively poor prognosis for systemic sclerosis and oropharyngeal cancer. The low incidence of patients with systemic sclerosis and oropharyngeal carcinoma together presents a clear case for a casuistic approach. Based upon our own experience, we can attest to the difficulty of treating such patients. However, we have no evidence to indicate that these patients have reduced tolerance to surgical treatments. The current study presents the case of a 47-year-old female with systemic sclerosis, who was diagnosed with oropharyngeal carcinoma. The patient initially tolerated radiotherapy treatment well, however post-radiotherapy complications occurred. Despite many enigmatic indications to the contrary, it appears that the complications in this instance may be due to late toxicity from radiotherapy. Systemic sclerosis is a chronic, progressive disease with an extremely poor prognosis. The incidence of malignant tumors in patients with systemic sclerosis is increased when compared with that of the general population. In certain malignancies, systemic sclerosis presents as a paraneoplastic process. The symptoms of sclerosis in the organs of the head and neck often overlap with symptoms of malignant diseases, which may increase the difficulty of a differential diagnosis. Additionally, the presence of sclerosis may complicate standard examination procedures, due to poor access to the oral cavity and oropharynx. When considering treatment options, it is important to evaluate the surgical and oncological risks to soft tissues of the head and neck with regard to both diseases, as well as the relatively poor prognosis for systemic sclerosis and oropharyngeal cancer. The low incidence of patients with systemic sclerosis and oropharyngeal carcinoma together presents a clear case for a casuistic approach. Based upon our own experience, we can attest to the difficulty of treating such patients. However, we have no evidence to indicate that these patients have reduced tolerance to surgical treatments. The current study presents the case of a 47-year-old female with systemic sclerosis, who was diagnosed with oropharyngeal carcinoma. The patient initially tolerated radiotherapy treatment well, however post-radiotherapy complications occurred. Despite many enigmatic indications to the contrary, it appears that the complications in this instance may be due to late toxicity from radiotherapy.
dcterms:title
Complications in the treatment of oropharyngeal carcinoma in patients with systemic sclerosis: A case report Complications in the treatment of oropharyngeal carcinoma in patients with systemic sclerosis: A case report
skos:prefLabel
Complications in the treatment of oropharyngeal carcinoma in patients with systemic sclerosis: A case report Complications in the treatment of oropharyngeal carcinoma in patients with systemic sclerosis: A case report
skos:notation
RIV/00216208:11120/15:43909167!RIV15-MSM-11120___
n3:aktivita
n11:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n5:8989907 n5:7426674 n5:9920781 n5:6235816
n3:druhVysledku
n6:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
77
n3:idVysledku
RIV/00216208:11120/15:43909167
n3:jazykVysledku
n7:eng
n3:klicovaSlova
systemic sclerosis; oropharyngeal carcinoma; autoimmune diseases
n3:klicoveSlovo
n13:systemic%20sclerosis n13:autoimmune%20diseases n13:oropharyngeal%20carcinoma
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[8853EEB60B49]
n3:nazevZdroje
Oncology Letters
n3:obor
n4:FF
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n12:2015
n3:svazekPeriodika
9
n3:tvurceVysledku
Valešová, Marie Hahn, Aleš Ambruš, Miloslav Čoček, Aleš
n3:wos
000346638300004
s:issn
1792-1074
s:numberOfPages
4
n17:doi
10.3892/ol.2014.2627
n10:organizacniJednotka
11120