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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F15%3A43909122%21RIV15-MSM-11120___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Knowledge about human papillomaviruses (HPV) types involved in anal cancers in some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution in a series of invasive anal cancers and anal intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN 2/3 cases and 496 anal cancers diagnosed from 1986 to 2011. After histopathological evaluation of formalin-fixed paraffin-embedded samples, HPV DNA detection and genotyping was performed using SPF-10/DEIA/LiPA(25) system (version 1). A subset of 116 cancers was further tested for p16(INK4a) expression, a cellular surrogate marker for HPV-associated transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance in the anal cancer data set. HPV DNA was detected in 88.3% of anal cancers (95% confidence interval [CI]: 85.1-91.0%) and in 95.3% of AIN 2/3 (95% CI: 84.2-99.4%). Among cancers, the highest prevalence was observed in warty-basaloid subtype of squamous cell carcinomas, in younger patients and in North American geographical region. There were no statistically significant differences in prevalence by gender. HPV16 was the most frequent HPV type detected in both cancers (80.7%) and AIN 2/3 lesions (75.4%). HPV18 was the second most common type in invasive cancers (3.6%). p16(INK4a) overexpression was found in 95% of HPV DNA-positive anal cancers. In view of the results of HPV DNA and high proportion of p16(INK4a) overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women. The large contribution of HPV16 reinforces the potential impact of HPV vaccines in the prevention of these lesions. Knowledge about human papillomaviruses (HPV) types involved in anal cancers in some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution in a series of invasive anal cancers and anal intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN 2/3 cases and 496 anal cancers diagnosed from 1986 to 2011. After histopathological evaluation of formalin-fixed paraffin-embedded samples, HPV DNA detection and genotyping was performed using SPF-10/DEIA/LiPA(25) system (version 1). A subset of 116 cancers was further tested for p16(INK4a) expression, a cellular surrogate marker for HPV-associated transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance in the anal cancer data set. HPV DNA was detected in 88.3% of anal cancers (95% confidence interval [CI]: 85.1-91.0%) and in 95.3% of AIN 2/3 (95% CI: 84.2-99.4%). Among cancers, the highest prevalence was observed in warty-basaloid subtype of squamous cell carcinomas, in younger patients and in North American geographical region. There were no statistically significant differences in prevalence by gender. HPV16 was the most frequent HPV type detected in both cancers (80.7%) and AIN 2/3 lesions (75.4%). HPV18 was the second most common type in invasive cancers (3.6%). p16(INK4a) overexpression was found in 95% of HPV DNA-positive anal cancers. In view of the results of HPV DNA and high proportion of p16(INK4a) overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women. The large contribution of HPV16 reinforces the potential impact of HPV vaccines in the prevention of these lesions.
dcterms:title
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide
skos:prefLabel
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide
skos:notation
RIV/00216208:11120/15:43909122!RIV15-MSM-11120___
n4:aktivita
n18:N
n4:aktivity
N
n4:cisloPeriodika
1
n4:dodaniDat
n10:2015
n4:domaciTvurceVysledku
n16:7449186
n4:druhVysledku
n8:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n5:predkladatel
n4:idSjednocenehoVysledku
191
n4:idVysledku
RIV/00216208:11120/15:43909122
n4:jazykVysledku
n9:eng
n4:klicovaSlova
vaccine; human papillomavirus; anal cancer
n4:klicoveSlovo
n11:vaccine n11:anal%20cancer n11:human%20papillomavirus
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[386A2FD32883]
n4:nazevZdroje
International Journal of Cancer
n4:obor
n17:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
34
n4:rokUplatneniVysledku
n10:2015
n4:svazekPeriodika
136
n4:tvurceVysledku
Mandys, Václav
n4:wos
000344011400011
s:issn
0020-7136
s:numberOfPages
10
n15:doi
10.1002/ijc.28963
n14:organizacniJednotka
11120