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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F15%3A43908495%21RIV15-MSM-11120___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
To determine changes in incidence of reactivation of Toxoplasma gondii infection, manifesting as toxoplasmic encephalitis, and to assess the immunological mechanisms controlling reactivation in HIV- infected patients, a Czech cohort of 502 HIV/T. gondii co-infected patients was followed for 2909 3 person-years. The incidence of toxoplasmic encephalitis between the periods before and after the introduction of combination antiretroviral therapy (cART) was compared. Toxoplasmic encephalitis was diagnosed in 21 patients. In those patients the geometric mean value of CD4+ T lymphocytes was 12 6 times lower than in patients with non-reactivated T. gondii infection but an additionally significant decline in CD8+ T lymphocytes (3 3-fold) and natural killer cells (4 3-fold) was observed. This confirms the significance of these parameters. A twelvefold decrease in Toxoplasma reactivation incidence (40 2 vs. 3 4/1000 person-years) between monitored periods was seen. In the cART era, Toxoplasma reactivation was observed only in patients with unrecognized HIV infection or refusing therapy. To determine changes in incidence of reactivation of Toxoplasma gondii infection, manifesting as toxoplasmic encephalitis, and to assess the immunological mechanisms controlling reactivation in HIV- infected patients, a Czech cohort of 502 HIV/T. gondii co-infected patients was followed for 2909 3 person-years. The incidence of toxoplasmic encephalitis between the periods before and after the introduction of combination antiretroviral therapy (cART) was compared. Toxoplasmic encephalitis was diagnosed in 21 patients. In those patients the geometric mean value of CD4+ T lymphocytes was 12 6 times lower than in patients with non-reactivated T. gondii infection but an additionally significant decline in CD8+ T lymphocytes (3 3-fold) and natural killer cells (4 3-fold) was observed. This confirms the significance of these parameters. A twelvefold decrease in Toxoplasma reactivation incidence (40 2 vs. 3 4/1000 person-years) between monitored periods was seen. In the cART era, Toxoplasma reactivation was observed only in patients with unrecognized HIV infection or refusing therapy.
dcterms:title
Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients
skos:prefLabel
Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients
skos:notation
RIV/00216208:11120/15:43908495!RIV15-MSM-11120___
n3:aktivita
n14:N
n3:aktivity
N
n3:cisloPeriodika
3
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n12:9590765
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
204
n3:idVysledku
RIV/00216208:11120/15:43908495
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Toxoplasma gondii; incidence; immunology; HIV/AIDS; Encephalitis
n3:klicoveSlovo
n8:immunology n8:incidence n8:Encephalitis n8:Toxoplasma%20gondii n8:HIV%2FAIDS
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[5A090F50D16F]
n3:nazevZdroje
Epidemiology and Infection
n3:obor
n13:FN
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n9:2015
n3:svazekPeriodika
143
n3:tvurceVysledku
Machala, Ladislav
n3:wos
000348646700018
s:issn
0950-2688
s:numberOfPages
8
n17:doi
10.1017/S0950268814001253
n4:organizacniJednotka
11120