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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F14%3A43908958%21RIV15-MSM-11120___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Schizophrenia is a complex neuropsychiatric disorder with variable symptomatology, traditionally divided into positive and negative symptoms, and cognitive deficits. However, the etiology of this disorder has yet to be fully understood. Recent findings suggest that alteration of the basic sense of self-awareness may be an essential distortion of schizophrenia spectrum disorders. In addition, extensive research of social and mentalizing abilities has stressed the role of distortion of social skills in schizophrenia.This article aims to propose and support a concept of a triple brain network model of the dysfunctional switching between default mode and central executive network (CEN) related to the aberrant activity of the salience network. This model could represent a unitary mechanism of a wide array of symptom domains present in schizophrenia including the deficit of self (self-awareness and self-representation) and theory of mind (ToM) dysfunctions along with the traditional positive, negative and cognitive domains. We review previous studies which document the dysfunctions of self and ToM in schizophrenia together with neuroimaging data that support the triple brain network model as a common neuronal substrate of this dysfunction. Schizophrenia is a complex neuropsychiatric disorder with variable symptomatology, traditionally divided into positive and negative symptoms, and cognitive deficits. However, the etiology of this disorder has yet to be fully understood. Recent findings suggest that alteration of the basic sense of self-awareness may be an essential distortion of schizophrenia spectrum disorders. In addition, extensive research of social and mentalizing abilities has stressed the role of distortion of social skills in schizophrenia.This article aims to propose and support a concept of a triple brain network model of the dysfunctional switching between default mode and central executive network (CEN) related to the aberrant activity of the salience network. This model could represent a unitary mechanism of a wide array of symptom domains present in schizophrenia including the deficit of self (self-awareness and self-representation) and theory of mind (ToM) dysfunctions along with the traditional positive, negative and cognitive domains. We review previous studies which document the dysfunctions of self and ToM in schizophrenia together with neuroimaging data that support the triple brain network model as a common neuronal substrate of this dysfunction.
dcterms:title
Bridging disparate symptoms of schizophrenia: a triple network dysfunction theory Bridging disparate symptoms of schizophrenia: a triple network dysfunction theory
skos:prefLabel
Bridging disparate symptoms of schizophrenia: a triple network dysfunction theory Bridging disparate symptoms of schizophrenia: a triple network dysfunction theory
skos:notation
RIV/00216208:11120/14:43908958!RIV15-MSM-11120___
n3:aktivita
n15:I n15:S n15:P
n3:aktivity
I, P(GA14-03627S), P(GAP303/12/1464), P(GBP304/12/G069), S
n3:cisloPeriodika
30 May
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n11:8377146 n11:6339824 n11:7744153 n11:9040293
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
5813
n3:idVysledku
RIV/00216208:11120/14:43908958
n3:jazykVysledku
n19:eng
n3:klicovaSlova
central executive network; salience network; default mode network; forward model; theory of mind; self; schizophrenia
n3:klicoveSlovo
n4:schizophrenia n4:theory%20of%20mind n4:salience%20network n4:default%20mode%20network n4:central%20executive%20network n4:forward%20model n4:self
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[F50E601DFE35]
n3:nazevZdroje
Frontiers in Behavioral Neuroscience
n3:obor
n9:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n12:GAP303%2F12%2F1464 n12:GA14-03627S n12:GBP304%2F12%2FG069
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
8
n3:tvurceVysledku
Španiel, Filip Horáček, Jiří Fajnerová, Iveta Nekovářová, Tereza
n3:wos
000336794600001
s:issn
1662-5153
s:numberOfPages
10
n18:doi
10.3389/fnbeh.2014.00171
n13:organizacniJednotka
11120