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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F14%3A43908954%21RIV15-MSM-11120___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
OBJECTIVES: Toxoplasma gondii, the protozoan parasite infecting about 30% population worldwide, is suspected to be the etiological agent of certain form of schizophrenia disease. Toxoplasma is known to change levels of certain neurotransmitters, cytokines and several hormones in both infected animals and humans. A common feature of toxoplasmosis and schizophrenia is a disorder of immune system. METHODS: Here we studied the levels of five neuro- and immunomodulatory steroids, selected hormones and lipids in sera of 173 schizophrenia patients. RESULTS: Toxoplasma infected schizophrenia patients expressed only insignificantly lower concentration of neuro-and immunomodulatory DHEA metabolites. Infected women had higher concentration of glucose while infected men had higher concentration of cholesterol and LDL cholesterol. No significant effect of human cytomegalovirus infection on the concentration of the above parameters was observed. The difference in the concentration of DHEA metabolites faded with the decrease of the concentration of anti-Toxoplasma IgG antibodies (i.e. with the duration of Toxoplasma infection) while the difference in the concentration of cholesterol and LDL-cholesterol increased with the decrease of the concentration of anti-Toxoplasma IgG antibodies. The prevalence of toxoplasmosis in male (53.2%) but not female (29.8%) schizophrenia patients was unusually high in comparison with prevalence of toxoplasmosis in a general population. OBJECTIVES: Toxoplasma gondii, the protozoan parasite infecting about 30% population worldwide, is suspected to be the etiological agent of certain form of schizophrenia disease. Toxoplasma is known to change levels of certain neurotransmitters, cytokines and several hormones in both infected animals and humans. A common feature of toxoplasmosis and schizophrenia is a disorder of immune system. METHODS: Here we studied the levels of five neuro- and immunomodulatory steroids, selected hormones and lipids in sera of 173 schizophrenia patients. RESULTS: Toxoplasma infected schizophrenia patients expressed only insignificantly lower concentration of neuro-and immunomodulatory DHEA metabolites. Infected women had higher concentration of glucose while infected men had higher concentration of cholesterol and LDL cholesterol. No significant effect of human cytomegalovirus infection on the concentration of the above parameters was observed. The difference in the concentration of DHEA metabolites faded with the decrease of the concentration of anti-Toxoplasma IgG antibodies (i.e. with the duration of Toxoplasma infection) while the difference in the concentration of cholesterol and LDL-cholesterol increased with the decrease of the concentration of anti-Toxoplasma IgG antibodies. The prevalence of toxoplasmosis in male (53.2%) but not female (29.8%) schizophrenia patients was unusually high in comparison with prevalence of toxoplasmosis in a general population.
dcterms:title
Difference of neuro- and immunomodulatory steroids and selected hormone and lipid concentrations between Toxoplasma-free and Toxoplasma-infected but not CMV-free and CMV-infected schizophrenia patients Difference of neuro- and immunomodulatory steroids and selected hormone and lipid concentrations between Toxoplasma-free and Toxoplasma-infected but not CMV-free and CMV-infected schizophrenia patients
skos:prefLabel
Difference of neuro- and immunomodulatory steroids and selected hormone and lipid concentrations between Toxoplasma-free and Toxoplasma-infected but not CMV-free and CMV-infected schizophrenia patients Difference of neuro- and immunomodulatory steroids and selected hormone and lipid concentrations between Toxoplasma-free and Toxoplasma-infected but not CMV-free and CMV-infected schizophrenia patients
skos:notation
RIV/00216208:11120/14:43908954!RIV15-MSM-11120___
n3:aktivita
n7:S n7:P n7:I n7:V
n3:aktivity
I, P(GAP303/11/1398), S, V
n3:cisloPeriodika
1
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n10:1965247
n3:druhVysledku
n5:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
11417
n3:idVysledku
RIV/00216208:11120/14:43908954
n3:jazykVysledku
n11:eng
n3:klicovaSlova
metabolites; manipulation hypothesis; psychiatry; schizophrenia; parasites; toxoplasmosis; cardiovascular diseases; heart disease; hypertensive heart disease; cholesterol; cortisol
n3:klicoveSlovo
n4:hypertensive%20heart%20disease n4:parasites n4:cortisol n4:cardiovascular%20diseases n4:schizophrenia n4:toxoplasmosis n4:psychiatry n4:metabolites n4:manipulation%20hypothesis n4:cholesterol n4:heart%20disease
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[B7123659B276]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n13:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n14:GAP303%2F11%2F1398
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
35
n3:tvurceVysledku
Mohr, Pavel
n3:wos
000340153500004
s:issn
0172-780X
s:numberOfPages
8
n16:organizacniJednotka
11120