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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F14%3A43908641%21RIV15-MSM-11120___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
The health-promoting effects of regular exercise are well known, and myokines may mediate some of these effects. The small leucine-rich proteoglycan decorin has been described as a myokine for some time. However, its regulation and impact on skeletal muscle has not been investigated in detail. In this study, we report decorin to be differentially expressed and released in response to muscle contraction using different approaches. Decorin is released from contracting human myotubes, and circulating decorin levels are increased in response to acute resistance exercise in humans. Moreover, decorin expression in skeletal muscle is increased in humans and mice after chronic training. Because decorin directly binds myostatin, a potent inhibitor of muscle growth, we investigated a potential function of decorin in the regulation of skeletal muscle growth. In vivo overexpression of decorin in murine skeletal muscle promoted expression of the pro-myogenic factor Mighty, which is negatively regulated by myostatin. We also found Myod1 and follistatin to be increased in response to decorin overexpression. Moreover, muscle-specific ubiquitin ligases atrogin1 and MuRF1, which are involved in atrophic pathways, were reduced by decorin overexpression. In summary, our findings suggest that decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle. The health-promoting effects of regular exercise are well known, and myokines may mediate some of these effects. The small leucine-rich proteoglycan decorin has been described as a myokine for some time. However, its regulation and impact on skeletal muscle has not been investigated in detail. In this study, we report decorin to be differentially expressed and released in response to muscle contraction using different approaches. Decorin is released from contracting human myotubes, and circulating decorin levels are increased in response to acute resistance exercise in humans. Moreover, decorin expression in skeletal muscle is increased in humans and mice after chronic training. Because decorin directly binds myostatin, a potent inhibitor of muscle growth, we investigated a potential function of decorin in the regulation of skeletal muscle growth. In vivo overexpression of decorin in murine skeletal muscle promoted expression of the pro-myogenic factor Mighty, which is negatively regulated by myostatin. We also found Myod1 and follistatin to be increased in response to decorin overexpression. Moreover, muscle-specific ubiquitin ligases atrogin1 and MuRF1, which are involved in atrophic pathways, were reduced by decorin overexpression. In summary, our findings suggest that decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle.
dcterms:title
The myokine decorin is regulated by contraction and involved in muscle hypertrophy The myokine decorin is regulated by contraction and involved in muscle hypertrophy
skos:prefLabel
The myokine decorin is regulated by contraction and involved in muscle hypertrophy The myokine decorin is regulated by contraction and involved in muscle hypertrophy
skos:notation
RIV/00216208:11120/14:43908641!RIV15-MSM-11120___
n3:aktivita
n13:S
n3:aktivity
S
n3:cisloPeriodika
2
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
Kolnes, Anders Jensen Kolnes, Kristoffer Jensen
n3:druhVysledku
n7:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
31267
n3:idVysledku
RIV/00216208:11120/14:43908641
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Exercise; Myokines; Skeletal muscle
n3:klicoveSlovo
n15:Myokines n15:Skeletal%20muscle n15:Exercise
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A3F0791424CC]
n3:nazevZdroje
Biochemical and Biophysical Research Communications
n3:obor
n12:FB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
450
n3:tvurceVysledku
Kolnes, Anders Jensen Kolnes, Kristoffer Jensen
n3:wos
000339861200027
s:issn
0006-291X
s:numberOfPages
6
n5:doi
10.1016/j.bbrc.2014.06.123
n14:organizacniJednotka
11120