This HTML5 document contains 54 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n16http://localhost/temp/predkladatel/
n11http://linked.opendata.cz/resource/domain/vavai/projekt/
n9http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n12http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
n15http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11120%2F14%3A43908457%21RIV15-MSM-11120___/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n7http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n14http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F14%3A43908457%21RIV15-MSM-11120___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to adult amphetamine (AMP) treatment in male and female rats. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male and female offspring (prenatally MA- or saline-exposed) were administered with AMP (5 mg/kg) or saline (1 ml/kg) in adulthood. Behaviour in unknown environment was examined in open field test (Laboras), active drug-seeking behaviour in conditioned place preference test (CPP), spatial memory in the Morris water maze (MWM), and levels of corticosterone (CORT) were analyzed by enzyme immunoassay (EIA). Our data demonstrate that in Laboras test, AMP treatment in adulthood increased general locomotion (time and distance travelled) regardless of the prenatal exposure and sex, while AMP increased exploratory activity (rearing) only in prenatally MA-exposed animals. AMP induced sensitization only in male rats, but not in females when tested drug-seeking behaviour in the CPP test. In the spatial memory MWM test, AMP worsened the performance only in females, but not in males. On the other hand, males swam faster after chronic AMP treatment regardless of the prenatal drug exposure. EIA analysis of CORT levels demonstrated higher level in females in all measurement settings. In males, prenatal MA exposure and chronic adult AMP treatment decreased CORT levels. Thus, our data demonstrated that adult AMP treatment affects behaviour of adult rats, their spatial memory and stress response in sex-specific manner. The effect is also influenced by prenatal drug exposure. The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to adult amphetamine (AMP) treatment in male and female rats. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male and female offspring (prenatally MA- or saline-exposed) were administered with AMP (5 mg/kg) or saline (1 ml/kg) in adulthood. Behaviour in unknown environment was examined in open field test (Laboras), active drug-seeking behaviour in conditioned place preference test (CPP), spatial memory in the Morris water maze (MWM), and levels of corticosterone (CORT) were analyzed by enzyme immunoassay (EIA). Our data demonstrate that in Laboras test, AMP treatment in adulthood increased general locomotion (time and distance travelled) regardless of the prenatal exposure and sex, while AMP increased exploratory activity (rearing) only in prenatally MA-exposed animals. AMP induced sensitization only in male rats, but not in females when tested drug-seeking behaviour in the CPP test. In the spatial memory MWM test, AMP worsened the performance only in females, but not in males. On the other hand, males swam faster after chronic AMP treatment regardless of the prenatal drug exposure. EIA analysis of CORT levels demonstrated higher level in females in all measurement settings. In males, prenatal MA exposure and chronic adult AMP treatment decreased CORT levels. Thus, our data demonstrated that adult AMP treatment affects behaviour of adult rats, their spatial memory and stress response in sex-specific manner. The effect is also influenced by prenatal drug exposure.
dcterms:title
Effect of amphetamine on adult male and female rats prenatally exposed to methamphetamine Effect of amphetamine on adult male and female rats prenatally exposed to methamphetamine
skos:prefLabel
Effect of amphetamine on adult male and female rats prenatally exposed to methamphetamine Effect of amphetamine on adult male and female rats prenatally exposed to methamphetamine
skos:notation
RIV/00216208:11120/14:43908457!RIV15-MSM-11120___
n4:aktivita
n17:S n17:P n17:I
n4:aktivity
I, P(GAP303/10/0580), S
n4:cisloPeriodika
1-2
n4:dodaniDat
n14:2015
n4:domaciTvurceVysledku
n9:6480543 n9:4987063 n9:6283101 n9:6877141 n9:4711491
n4:druhVysledku
n18:J
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
13119
n4:idVysledku
RIV/00216208:11120/14:43908457
n4:jazykVysledku
n13:eng
n4:klicovaSlova
corticosterone; spatial memory; drug-seeking behavior; locomotion; Morris water maze; Conditioned place preference; Open field; amphetamine; methamphetamine; prenatal drug exposure
n4:klicoveSlovo
n7:Open%20field n7:locomotion n7:amphetamine n7:prenatal%20drug%20exposure n7:drug-seeking%20behavior n7:corticosterone n7:spatial%20memory n7:methamphetamine n7:Morris%20water%20maze n7:Conditioned%20place%20preference
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[D527B0078E0D]
n4:nazevZdroje
Prague Medical Report
n4:obor
n8:FH
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
5
n4:projekt
n11:GAP303%2F10%2F0580
n4:rokUplatneniVysledku
n14:2014
n4:svazekPeriodika
115
n4:tvurceVysledku
Macúchová, Eva Šlamberová, Romana Štofková, Andrea Nohejlová, Kateryna Jurčovičová, Jana
s:issn
1214-6994
s:numberOfPages
17
n16:organizacniJednotka
11120