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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F14%3A43908178%21RIV14-MSM-11120___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Objective. To characterize GEP-NENs in routine biopsies and surgical specimen in the Czech Republic and to evaluate how WHO Classification (2010) is acceptable in diagnostic practice. Methods. Paraffin-embedded blocks and bioptic reports were collected from 17 departments of pathology. Histologic slides were stained with H&E and immunohistologically for CgA, synaptophysin, and Ki-67. Results. Out of 28 gastric NENs, there were 22 NETs, G1, 5 NETs, G2, and 1 NEC. Ten duodenal NENs were NETs, G1. Among 27 NENs of jejunum and ileum, 23 were NETs, G1, 2 NETs, G2, and 1 NEC and 1 mixed adenoneuroendocrine carcinoma (MANEC). Among 42 appendiceal “incidentalomas”, 39 were NETs G1, 2 goblet cell carcinoids, and 1 MANEC. Out of 34 large intestinal NENs, 30 were NETs, G1, 3 NETs, G2, and 1 NEC. One small intestinal and 6 large bowel neoplasms were reclassified as poorly differentiated adenocarcinomas. In 12 pancreatic NENs, there were 7 NETs, G1, 3 NETs, G2, and 2 NECs. Conclusions. Our study demonstrates differences in GEP-NENs frequency in sites of origin in our region, comparing to other countries. Regarding routine bioptic diagnostics, we gave evidence that the WHO 2010 classification of NENs is fully acceptable for exact categorisation of tumours. Objective. To characterize GEP-NENs in routine biopsies and surgical specimen in the Czech Republic and to evaluate how WHO Classification (2010) is acceptable in diagnostic practice. Methods. Paraffin-embedded blocks and bioptic reports were collected from 17 departments of pathology. Histologic slides were stained with H&E and immunohistologically for CgA, synaptophysin, and Ki-67. Results. Out of 28 gastric NENs, there were 22 NETs, G1, 5 NETs, G2, and 1 NEC. Ten duodenal NENs were NETs, G1. Among 27 NENs of jejunum and ileum, 23 were NETs, G1, 2 NETs, G2, and 1 NEC and 1 mixed adenoneuroendocrine carcinoma (MANEC). Among 42 appendiceal “incidentalomas”, 39 were NETs G1, 2 goblet cell carcinoids, and 1 MANEC. Out of 34 large intestinal NENs, 30 were NETs, G1, 3 NETs, G2, and 1 NEC. One small intestinal and 6 large bowel neoplasms were reclassified as poorly differentiated adenocarcinomas. In 12 pancreatic NENs, there were 7 NETs, G1, 3 NETs, G2, and 2 NECs. Conclusions. Our study demonstrates differences in GEP-NENs frequency in sites of origin in our region, comparing to other countries. Regarding routine bioptic diagnostics, we gave evidence that the WHO 2010 classification of NENs is fully acceptable for exact categorisation of tumours.
dcterms:title
Spectrum of Gastroenteropancreatic NENs in Routine Histological Examinations of Bioptic and Surgical Specimen: A Study of 161 Cases Collected from 17 Departments of Pathology in the Czech Republic Spectrum of Gastroenteropancreatic NENs in Routine Histological Examinations of Bioptic and Surgical Specimen: A Study of 161 Cases Collected from 17 Departments of Pathology in the Czech Republic
skos:prefLabel
Spectrum of Gastroenteropancreatic NENs in Routine Histological Examinations of Bioptic and Surgical Specimen: A Study of 161 Cases Collected from 17 Departments of Pathology in the Czech Republic Spectrum of Gastroenteropancreatic NENs in Routine Histological Examinations of Bioptic and Surgical Specimen: A Study of 161 Cases Collected from 17 Departments of Pathology in the Czech Republic
skos:notation
RIV/00216208:11120/14:43908178!RIV14-MSM-11120___
n3:predkladatel
n4:orjk%3A11120
n6:aktivita
n8:I
n6:aktivity
I
n6:cisloPeriodika
Art. ID 373828
n6:dodaniDat
n18:2014
n6:domaciTvurceVysledku
n17:6116124 n17:7449186
n6:druhVysledku
n7:J
n6:duvernostUdaju
n19:S
n6:entitaPredkladatele
n9:predkladatel
n6:idSjednocenehoVysledku
46595
n6:idVysledku
RIV/00216208:11120/14:43908178
n6:jazykVysledku
n15:eng
n6:klicovaSlova
Routine Histological Examinations; NENs; Gastroenteropancreatis
n6:klicoveSlovo
n10:Gastroenteropancreatis n10:Routine%20Histological%20Examinations n10:NENs
n6:kodStatuVydavatele
US - Spojené státy americké
n6:kontrolniKodProRIV
[FAF2EDFF3E56]
n6:nazevZdroje
Gastroenterology Research and Practice
n6:obor
n12:FP
n6:pocetDomacichTvurcuVysledku
2
n6:pocetTvurcuVysledku
2
n6:rokUplatneniVysledku
n18:2014
n6:svazekPeriodika
-
n6:tvurceVysledku
Jirásek, Tomáš Mandys, Václav
n6:wos
000332299900001
s:issn
1687-6121
s:numberOfPages
5
n11:doi
10.1155/2014/373828
n16:organizacniJednotka
11120