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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F14%3A43908039%21RIV15-MSM-11120___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Ghrelin, an orexigenic (appetite stimulating) peptide activates binding sites in the ventral tegmental area (a structure linked with the neural reward system) allowing it to participate in reward-seeking behavior. An increasing number of studies over the past few years have demonstrated ghrelin’s role in alcohol, cocaine, and nicotine abuse. However, the role of ghrelin, in opioid effects, has rarely been examined. The aim of the present study was to ascertain whether a ghrelin antagonist (JMV2959) was able to inhibit markers of morphine-induced activation of the neural reward system, namely morphine-induced increase of dopamine in the nucleus accumbens and behavioral changes in rats. Methods: We used in vivo microdialysis to determine changes of dopamine and its metabolites in the nucleus accumbens shell in rats following morphine (MO, 5, 10 mg/kg s.c.) administration with and without ghrelin antagonist pretreatment (JMV2959, 3, 6 mg/kg i.p., 20 min before MO). Induced behavioral changes were simultaneously monitored. Results: JMV2959 significantly and dose dependently reduced MO-induced dopamine release in the nucleus accumbens shell and affected concentration of by-products associated with dopamine metabolism: 3-methoxytyramine (3-MT), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA). JMV2959 pretreatment also significantly reduced MO-induced behavioral stimulation, especially stereotyped behavior. Conclusions: Ghrelin secretagogue receptors (GHS-R1A) appear to be involved in the opioid-induced changes in the mesolimbic dopaminergic system associated with the reward processing. Ghrelin, an orexigenic (appetite stimulating) peptide activates binding sites in the ventral tegmental area (a structure linked with the neural reward system) allowing it to participate in reward-seeking behavior. An increasing number of studies over the past few years have demonstrated ghrelin’s role in alcohol, cocaine, and nicotine abuse. However, the role of ghrelin, in opioid effects, has rarely been examined. The aim of the present study was to ascertain whether a ghrelin antagonist (JMV2959) was able to inhibit markers of morphine-induced activation of the neural reward system, namely morphine-induced increase of dopamine in the nucleus accumbens and behavioral changes in rats. Methods: We used in vivo microdialysis to determine changes of dopamine and its metabolites in the nucleus accumbens shell in rats following morphine (MO, 5, 10 mg/kg s.c.) administration with and without ghrelin antagonist pretreatment (JMV2959, 3, 6 mg/kg i.p., 20 min before MO). Induced behavioral changes were simultaneously monitored. Results: JMV2959 significantly and dose dependently reduced MO-induced dopamine release in the nucleus accumbens shell and affected concentration of by-products associated with dopamine metabolism: 3-methoxytyramine (3-MT), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA). JMV2959 pretreatment also significantly reduced MO-induced behavioral stimulation, especially stereotyped behavior. Conclusions: Ghrelin secretagogue receptors (GHS-R1A) appear to be involved in the opioid-induced changes in the mesolimbic dopaminergic system associated with the reward processing.
dcterms:title
Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats
skos:prefLabel
Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats
skos:notation
RIV/00216208:11120/14:43908039!RIV15-MSM-11120___
n4:aktivita
n11:S n11:P n11:I
n4:aktivity
I, P(LO1215), S
n4:cisloPeriodika
14
n4:dodaniDat
n12:2015
n4:domaciTvurceVysledku
n5:8183732 n5:7441991 n5:7286600 n5:6137997
n4:druhVysledku
n9:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
18352
n4:idVysledku
RIV/00216208:11120/14:43908039
n4:jazykVysledku
n18:eng
n4:klicovaSlova
microdialysis; stereotyped behavior; dopamine metabolites; dopamine; nucleus accumbens shell; neural reward system; ghrelin; morphine
n4:klicoveSlovo
n8:nucleus%20accumbens%20shell n8:stereotyped%20behavior n8:dopamine n8:microdialysis n8:morphine n8:ghrelin n8:neural%20reward%20system n8:dopamine%20metabolites
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[F897BA717B61]
n4:nazevZdroje
Psychopharmacology
n4:obor
n7:FH
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
5
n4:projekt
n13:LO1215
n4:rokUplatneniVysledku
n12:2014
n4:svazekPeriodika
231
n4:tvurceVysledku
Šustková-Fišerová, Magdaléna Kršiak, Miloslav Jeřábek, Pavel Havlíčková, Tereza
n4:wos
000338634100016
s:issn
0033-3158
s:numberOfPages
10
n14:doi
10.1007/s00213-014-3466-9
n19:organizacniJednotka
11120