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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F14%3A43908016%21RIV15-MSM-11120___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Context: Soluble CD163 was suggested as a biomarker of insulin sensitivity and CD163 mRNA expression representing macrophage content in adipose tissue (AT). Objective: The aim of this study was to investigate, in cross-sectional and prospective design, the relationship between sCD163 circulating levels and, CD163 mRNA expression in adipose tissue and insulin sensitivity assessed by euglycemic-hyperinsulinemic clamp. Design, Setting, Participants, and Interventions: Two cohorts of subjects were examined in the study. Cohort 1: forty-two women with wide range of BMI (17-48 kg/m2); Cohort 2: twenty-seven obese women, who followed a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Main Outcome Measures: Serum levels of CD163 and mRNA expression of CD163 and CD68 in subcutaneous and visceral AT were determined, and insulin sensitivity (expressed as glucose disposal rate (GDR)) was measured in Cohort I. In Cohort 2, serum levels of CD163, mRNA expressions of CD163, CD68, and CD163-shedding factors (TACE and TIPM3) in subcutaneous AT were examined and GDR was measured before and during dietary intervention. Results: In Cohort 1, circulating sCD163 correlated with CD163 mRNA levels in both subcutaneous and visceral AT. sCD163 and CD163 mRNA expression in both fat depots correlated with GDR. In Cohort 2, the diet-induced changes of sCD163 levels did not correlate with those of CD163, CD 68, TACE and TIMP3 mRNA levels. Although the pattern of the diet-induced change of sCD163 paralleled that of GDR there was no correlation between the changes of these two variables. Conclusion: sCD163 correlates with CD163 mRNA expression in subcutaneous and visceral AT and with whole-body insulin sensitivity in steady state condition. These associations are not observed in respect to the diet-induced changes during weight-reducing hypocaloric diet. Context: Soluble CD163 was suggested as a biomarker of insulin sensitivity and CD163 mRNA expression representing macrophage content in adipose tissue (AT). Objective: The aim of this study was to investigate, in cross-sectional and prospective design, the relationship between sCD163 circulating levels and, CD163 mRNA expression in adipose tissue and insulin sensitivity assessed by euglycemic-hyperinsulinemic clamp. Design, Setting, Participants, and Interventions: Two cohorts of subjects were examined in the study. Cohort 1: forty-two women with wide range of BMI (17-48 kg/m2); Cohort 2: twenty-seven obese women, who followed a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Main Outcome Measures: Serum levels of CD163 and mRNA expression of CD163 and CD68 in subcutaneous and visceral AT were determined, and insulin sensitivity (expressed as glucose disposal rate (GDR)) was measured in Cohort I. In Cohort 2, serum levels of CD163, mRNA expressions of CD163, CD68, and CD163-shedding factors (TACE and TIPM3) in subcutaneous AT were examined and GDR was measured before and during dietary intervention. Results: In Cohort 1, circulating sCD163 correlated with CD163 mRNA levels in both subcutaneous and visceral AT. sCD163 and CD163 mRNA expression in both fat depots correlated with GDR. In Cohort 2, the diet-induced changes of sCD163 levels did not correlate with those of CD163, CD 68, TACE and TIMP3 mRNA levels. Although the pattern of the diet-induced change of sCD163 paralleled that of GDR there was no correlation between the changes of these two variables. Conclusion: sCD163 correlates with CD163 mRNA expression in subcutaneous and visceral AT and with whole-body insulin sensitivity in steady state condition. These associations are not observed in respect to the diet-induced changes during weight-reducing hypocaloric diet.
dcterms:title
Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction
skos:prefLabel
Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction
skos:notation
RIV/00216208:11120/14:43908016!RIV15-MSM-11120___
n3:aktivita
n11:I n11:P
n3:aktivity
I, P(GAP301/11/0748)
n3:cisloPeriodika
3
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n4:9227121 n4:2809508 n4:2450569 n4:7297432 n4:9021000 n4:7508808 n4:8835659 n4:4377974 n4:3966577
n3:druhVysledku
n10:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
45908
n3:idVysledku
RIV/00216208:11120/14:43908016
n3:jazykVysledku
n16:eng
n3:klicovaSlova
adipose tissue; insulin sensitivity
n3:klicoveSlovo
n6:adipose%20tissue n6:insulin%20sensitivity
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[C1C79475F944]
n3:nazevZdroje
Journal of Clinical Endocrinology and Metabolism
n3:obor
n9:FB
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
10
n3:projekt
n18:GAP301%2F11%2F0748
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
99
n3:tvurceVysledku
Kováčová, Zuzana Tencerová, Michaela Šiklová, Michaela Štich, Vladimír Langin, Dominique Mališová, Lucia Polák, Jan Rossmeislová, Lenka Kračmerová, Jana Klimčáková, Eva
n3:wos
000333461600019
s:issn
0021-972X
s:numberOfPages
8
n19:doi
10.1210/jc.2013-3348
n15:organizacniJednotka
11120