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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F14%3A43907956%21RIV15-MSM-11120___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Frontotemporal lobar degenerations are clinically, genetically, and molecularly heterogeneous diseases characterized by mainly frontal and temporal atrophy and affecting behavioral, language, cognitive, and motor functions. The term frontotemporal dementia incorporates 3 distinct clinical syndromes seen in frontotemporal degenerations: behavioral variant of frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia. Progressive supranuclear palsy syndrome, corticobasal syndrome, and motor neuron disease syndrome are also associated with frontotemporal lobar degenerations. The neuropathologic hallmark of frontotemporal lobar degenerations is accumulation of abnormal proteins in the cytoplasm and nuclei of neurons and glial cells. Proteins involved in pathologic processes that represent the basis for frontotemporal lobar degeneration classification are tau protein, transactive response DNA-binding protein of 43 kDa, and %22fused in sarcoma%22 protein. The aim of this review is to provide a summary of practical approaches for neuropathologic diagnostics of the rapidly evolving classifications of frontotemporal lobar degenerations Frontotemporal lobar degenerations are clinically, genetically, and molecularly heterogeneous diseases characterized by mainly frontal and temporal atrophy and affecting behavioral, language, cognitive, and motor functions. The term frontotemporal dementia incorporates 3 distinct clinical syndromes seen in frontotemporal degenerations: behavioral variant of frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia. Progressive supranuclear palsy syndrome, corticobasal syndrome, and motor neuron disease syndrome are also associated with frontotemporal lobar degenerations. The neuropathologic hallmark of frontotemporal lobar degenerations is accumulation of abnormal proteins in the cytoplasm and nuclei of neurons and glial cells. Proteins involved in pathologic processes that represent the basis for frontotemporal lobar degeneration classification are tau protein, transactive response DNA-binding protein of 43 kDa, and %22fused in sarcoma%22 protein. The aim of this review is to provide a summary of practical approaches for neuropathologic diagnostics of the rapidly evolving classifications of frontotemporal lobar degenerations
dcterms:title
Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations A Practical Approach Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations A Practical Approach
skos:prefLabel
Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations A Practical Approach Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations A Practical Approach
skos:notation
RIV/00216208:11120/14:43907956!RIV15-MSM-11120___
n3:aktivita
n17:S
n3:aktivity
S
n3:cisloPeriodika
1
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n7:7678827 n7:4091507
n3:druhVysledku
n18:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
9417
n3:idVysledku
RIV/00216208:11120/14:43907956
n3:jazykVysledku
n12:eng
n3:klicovaSlova
practical approach; frontotemporal lobar degenerations; diagnosis; classification
n3:klicoveSlovo
n11:classification n11:diagnosis n11:frontotemporal%20lobar%20degenerations n11:practical%20approach
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[07CBFC9CF316]
n3:nazevZdroje
Archives of Pathology & Laboratory Medicine
n3:obor
n4:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
138
n3:tvurceVysledku
Rohan, Zdeněk Matěj, Radoslav
n3:wos
000339549400020
s:issn
0003-9985
s:numberOfPages
7
n10:doi
10.5858/arpa.2012-0510-RS
n13:organizacniJednotka
11120