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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F14%3A43907649%21RIV15-MSM-11120___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Although the effects of glucocorticoids on proliferation, differentiation and apoptosis are well known, and steroid hormones have been identified to play a role in pathogenesis and the development of various cancers, limited data are available regarding the relationship between the local metabolism of glucocorticoids and colorectal adenocarcinoma (CRC) formation. Glucocorticoid metabolism is determined by 11beta-hydroxysteroid dehydrogenases type 1 and 2 (11HSD1, 11HSD2), which increase the local concentration of cortisol due to the reduction of cortisone, or decrease this concentration due to the oxidation of cortisol. The objective of this study was to evaluate the extent of 11HSD1 and 11HSD2 mRNA in pre-malignant colorectal polyps and in CRC. The specimens were retrieved from patients by endoscopic or surgical resection and the expression of 11HSD1 and 11HSD2 was measured by real-time PCR. The polyps were of the following histological types: hyperplastic polyps and adenomas with low- or high-grade dysplasia. The neoplastic tissue of CRC obtained during tumor surgery was also studied. It was found that 11HSD2 was not only downregulated in CRC but already in the early stages of neoplastic transformation (adenoma with low-grade dysplasia). In contrast, the level of 11HSD1 was significantly increased in CRC but not in pre-malignant polyps. The results demonstrate that the downregulation of 11HSD2 gene expression is a typical feature of the development of colorectal polypous lesions and their transformation into CRC. Although the effects of glucocorticoids on proliferation, differentiation and apoptosis are well known, and steroid hormones have been identified to play a role in pathogenesis and the development of various cancers, limited data are available regarding the relationship between the local metabolism of glucocorticoids and colorectal adenocarcinoma (CRC) formation. Glucocorticoid metabolism is determined by 11beta-hydroxysteroid dehydrogenases type 1 and 2 (11HSD1, 11HSD2), which increase the local concentration of cortisol due to the reduction of cortisone, or decrease this concentration due to the oxidation of cortisol. The objective of this study was to evaluate the extent of 11HSD1 and 11HSD2 mRNA in pre-malignant colorectal polyps and in CRC. The specimens were retrieved from patients by endoscopic or surgical resection and the expression of 11HSD1 and 11HSD2 was measured by real-time PCR. The polyps were of the following histological types: hyperplastic polyps and adenomas with low- or high-grade dysplasia. The neoplastic tissue of CRC obtained during tumor surgery was also studied. It was found that 11HSD2 was not only downregulated in CRC but already in the early stages of neoplastic transformation (adenoma with low-grade dysplasia). In contrast, the level of 11HSD1 was significantly increased in CRC but not in pre-malignant polyps. The results demonstrate that the downregulation of 11HSD2 gene expression is a typical feature of the development of colorectal polypous lesions and their transformation into CRC.
dcterms:title
Expression of 11 beta-hydroxysteroid dehydrogenase type 2 is deregulated in colon carcinoma Expression of 11 beta-hydroxysteroid dehydrogenase type 2 is deregulated in colon carcinoma
skos:prefLabel
Expression of 11 beta-hydroxysteroid dehydrogenase type 2 is deregulated in colon carcinoma Expression of 11 beta-hydroxysteroid dehydrogenase type 2 is deregulated in colon carcinoma
skos:notation
RIV/00216208:11120/14:43907649!RIV15-MSM-11120___
n3:aktivita
n16:I n16:S n16:P
n3:aktivity
I, P(GA13-08304S), S
n3:cisloPeriodika
4
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n4:7449186 n4:9148167 n4:4170563 n4:7553498 n4:6397743 n4:4455991
n3:druhVysledku
n18:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
16165
n3:idVysledku
RIV/00216208:11120/14:43907649
n3:jazykVysledku
n12:eng
n3:klicovaSlova
beta-hydroxysteroid dehydrogenase type 2; 11β-hydroxysteroid dehydrogenase type 1; colorectal cancer
n3:klicoveSlovo
n10:colorectal%20cancer n10:beta-hydroxysteroid%20dehydrogenase%20type%202 n10:11%CE%B2-hydroxysteroid%20dehydrogenase%20type%201
n3:kodStatuVydavatele
ES - Španělské království
n3:kontrolniKodProRIV
[28BE339FD239]
n3:nazevZdroje
Histology and Histopathology
n3:obor
n13:FD
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
9
n3:projekt
n14:GA13-08304S
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
29
n3:tvurceVysledku
Moravec, Martin Zádorová, Zdeňka Hajer, Jan Švec, Jiří Kment, Milan Mandys, Václav
n3:wos
000333756800008
s:issn
0213-3911
s:numberOfPages
8
n7:organizacniJednotka
11120