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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F13%3A43908361%21RIV14-MSM-11120___
rdf:type
skos:Concept n8:Vysledek
dcterms:description
Bipolar disorder (BD) is a lifelong severe psychiatric condition with high morbidity, disability and excess mortality. The longitudinal clinical trajectory of BD is significantly modified by pharmacological treatment(s), both in acute and in long-term stages. However, a large proportion of BD patients have inadequate response to pharmacological treatments. Pharmacogenomic research may lead to the identification of molecular predictors of treatment response. When integrated with clinical information, pharmacogenomic findings may be used in the future to determine the probability of response/nonresponse to treatment on an individual basis. Here we present a selective review of pharmacogenomic findings in BD. In light of the evidence suggesting a genetic effect of lithium reponse in BD, we focused particularly on the pharmacogenomic literature relevant to this trait. The article contributes a detailed overview of the current status of pharmacogenomics in BD and offers a perspective on the challenges that can hinder its transition to personalized healthcare. Bipolar disorder (BD) is a lifelong severe psychiatric condition with high morbidity, disability and excess mortality. The longitudinal clinical trajectory of BD is significantly modified by pharmacological treatment(s), both in acute and in long-term stages. However, a large proportion of BD patients have inadequate response to pharmacological treatments. Pharmacogenomic research may lead to the identification of molecular predictors of treatment response. When integrated with clinical information, pharmacogenomic findings may be used in the future to determine the probability of response/nonresponse to treatment on an individual basis. Here we present a selective review of pharmacogenomic findings in BD. In light of the evidence suggesting a genetic effect of lithium reponse in BD, we focused particularly on the pharmacogenomic literature relevant to this trait. The article contributes a detailed overview of the current status of pharmacogenomics in BD and offers a perspective on the challenges that can hinder its transition to personalized healthcare.
dcterms:title
Pharmacogenomics of bipolar disorder Pharmacogenomics of bipolar disorder
skos:prefLabel
Pharmacogenomics of bipolar disorder Pharmacogenomics of bipolar disorder
skos:notation
RIV/00216208:11120/13:43908361!RIV14-MSM-11120___
n8:predkladatel
n9:orjk%3A11120
n3:aktivita
n16:N
n3:aktivity
N
n3:cisloPeriodika
6
n3:dodaniDat
n13:2014
n3:domaciTvurceVysledku
n18:8421382
n3:druhVysledku
n17:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
95995
n3:idVysledku
RIV/00216208:11120/13:43908361
n3:jazykVysledku
n5:eng
n3:klicovaSlova
personalized medicine; mood stabilizers; lithium; GWAS; gene ontology; gene expression; antipsychotics; antidepressants
n3:klicoveSlovo
n12:gene%20expression n12:GWAS n12:lithium n12:antidepressants n12:mood%20stabilizers n12:personalized%20medicine n12:antipsychotics n12:gene%20ontology
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[A2293F0F872A]
n3:nazevZdroje
Pharmacogenomics
n3:obor
n6:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n13:2013
n3:svazekPeriodika
14
n3:tvurceVysledku
Alda, Martin
n3:wos
000317405300016
s:issn
1462-2416
s:numberOfPages
20
n15:organizacniJednotka
11120