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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F13%3A43908292%21RIV14-MSM-11120___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Objective:To consider associations between the latest/nadir CD4(+) cell count, and time spent with CD4(+) cell count less than 200cells/l (duration of immune depression), and myocardial infarction (MI), coronary heart disease (CHD), stroke, or cardiovascular disease (CVD) (CHD or stroke) in 33301 HIV-positive individuals.Design:Longitudinal cohort study.Methods:Analyses were undertaken using Poisson regression. To investigate whether analyses of stroke were robust to the type of endpoint, we additionally included stroke-like events and rejected strokes into the stroke endpoint.Results:Participants experienced 716 MI, 1056 CHD, 303 stroke, and 1284 CVD events. Whereas there was no evidence of a higher MI/CHD risk in those with lower latest/nadir CD4(+) cell counts after adjustment [current CD4(+)<100cells/l: relative rate (95% confidence interval) 0.96 (0.62-1.50) for MI, 0.89 (0.30-2.36) for CHD; nadir CD4(+)<100cells/l: 1.36 (0.57-3.23) for MI, 0.98 (0.45-2.16) for CHD], stroke and CVD rates were higher in those with a latest CD4(+) cell count less than 100cells/l [2.26 (1.29-3.94) and 1.14 (0.84-1.56), respectively]. All events occurred less frequently in those who had not experienced immune depression, although evidence for a linear association with duration of immune depression was weak. The association between stroke risk and the latest CD4(+) cell count strengthened as stroke-like and rejected strokes were included; conversely, associations with established stroke risk factors weakened.Conclusion:We do not find strong evidence that HIV-positive individuals with a low CD4(+) cell count are more likely to experience MI/CHD. Although strokes appear to occur more commonly at low CD4(+) cell counts, this may be partly explained by misclassification or other biases. Objective:To consider associations between the latest/nadir CD4(+) cell count, and time spent with CD4(+) cell count less than 200cells/l (duration of immune depression), and myocardial infarction (MI), coronary heart disease (CHD), stroke, or cardiovascular disease (CVD) (CHD or stroke) in 33301 HIV-positive individuals.Design:Longitudinal cohort study.Methods:Analyses were undertaken using Poisson regression. To investigate whether analyses of stroke were robust to the type of endpoint, we additionally included stroke-like events and rejected strokes into the stroke endpoint.Results:Participants experienced 716 MI, 1056 CHD, 303 stroke, and 1284 CVD events. Whereas there was no evidence of a higher MI/CHD risk in those with lower latest/nadir CD4(+) cell counts after adjustment [current CD4(+)<100cells/l: relative rate (95% confidence interval) 0.96 (0.62-1.50) for MI, 0.89 (0.30-2.36) for CHD; nadir CD4(+)<100cells/l: 1.36 (0.57-3.23) for MI, 0.98 (0.45-2.16) for CHD], stroke and CVD rates were higher in those with a latest CD4(+) cell count less than 100cells/l [2.26 (1.29-3.94) and 1.14 (0.84-1.56), respectively]. All events occurred less frequently in those who had not experienced immune depression, although evidence for a linear association with duration of immune depression was weak. The association between stroke risk and the latest CD4(+) cell count strengthened as stroke-like and rejected strokes were included; conversely, associations with established stroke risk factors weakened.Conclusion:We do not find strong evidence that HIV-positive individuals with a low CD4(+) cell count are more likely to experience MI/CHD. Although strokes appear to occur more commonly at low CD4(+) cell counts, this may be partly explained by misclassification or other biases.
dcterms:title
Associations between immune depression and cardiovascular events in HIV infection Associations between immune depression and cardiovascular events in HIV infection
skos:prefLabel
Associations between immune depression and cardiovascular events in HIV infection Associations between immune depression and cardiovascular events in HIV infection
skos:notation
RIV/00216208:11120/13:43908292!RIV14-MSM-11120___
n5:predkladatel
n6:orjk%3A11120
n4:aktivita
n17:N
n4:aktivity
N
n4:cisloPeriodika
17
n4:dodaniDat
n7:2014
n4:domaciTvurceVysledku
n11:9590765
n4:druhVysledku
n16:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
62361
n4:idVysledku
RIV/00216208:11120/13:43908292
n4:jazykVysledku
n15:eng
n4:klicovaSlova
myocardial infarction; CD4(+) lymphocyte count; cardiovascular disease; HIV infection
n4:klicoveSlovo
n13:myocardial%20infarction n13:CD4%28%2B%29%20lymphocyte%20count n13:cardiovascular%20disease n13:HIV%20infection
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[C8797F9AACA2]
n4:nazevZdroje
AIDS
n4:obor
n12:FN
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
709
n4:rokUplatneniVysledku
n7:2013
n4:svazekPeriodika
27
n4:tvurceVysledku
Machala, Ladislav
n4:wos
000326841800008
s:issn
0269-9370
s:numberOfPages
14
n10:organizacniJednotka
11120