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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F13%3A43907837%21RIV14-MSM-11120___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The aim of the study was to assess the immunohistochemical (IHC) profiles of SRC3, Pax2, ER, PgR, Her2, EGFR, CK5/6, and Ki67 proteins in breast-cancer brain metastasis. The study utilized tumor samples from 30 metastatic patients and calculated correlations between all IHC variables. In fourteen cases, primary breast cancers paired with secondary deposits were analyzed. We evaluated the association between IHC status in the primary and secondary deposits, grade, and histotype of the tumors. The examination of the metastatic deposits in all 30 patients resulted in positive detection in the following cases: SRC3 in 20 cases (66.6%), Pax2 in 22 (73.3%), ER in 22 (73.3%), PgR in 25 (83.3%), Her2 in 10 (33.3%), EGFR in 12 (40%), CK5/6 in 7 (23.3%), and Ki67 in 23 (76.6%). Grade 2 was found in 13.3% of all patients, and grade 3 in 86.7%. SRC3 and Pax2 were positive in both G2 and G3. Invasive lobular carcinoma and invasive ductal carcinoma were diagnosed in 23.3% and 76.7% of cases, respectively. There were no differences between the IHC expression of the studied proteins in either grading or histotype of the tumors. In the IHC profiles, which included SRC3, Pax2, ER, PgR, Her2, CK5/6, Ki67, and EGFR, we found no statistically significant differences between the primary cancer and the brain metastasis. In our study of metastatic breast carcinoma deposits, there was no correlation between SRC3, Pax2 status and histotype, and tumor grade. The IHC status of the paired primary and metastatic deposits did not differ in a statistically significant manner. The aim of the study was to assess the immunohistochemical (IHC) profiles of SRC3, Pax2, ER, PgR, Her2, EGFR, CK5/6, and Ki67 proteins in breast-cancer brain metastasis. The study utilized tumor samples from 30 metastatic patients and calculated correlations between all IHC variables. In fourteen cases, primary breast cancers paired with secondary deposits were analyzed. We evaluated the association between IHC status in the primary and secondary deposits, grade, and histotype of the tumors. The examination of the metastatic deposits in all 30 patients resulted in positive detection in the following cases: SRC3 in 20 cases (66.6%), Pax2 in 22 (73.3%), ER in 22 (73.3%), PgR in 25 (83.3%), Her2 in 10 (33.3%), EGFR in 12 (40%), CK5/6 in 7 (23.3%), and Ki67 in 23 (76.6%). Grade 2 was found in 13.3% of all patients, and grade 3 in 86.7%. SRC3 and Pax2 were positive in both G2 and G3. Invasive lobular carcinoma and invasive ductal carcinoma were diagnosed in 23.3% and 76.7% of cases, respectively. There were no differences between the IHC expression of the studied proteins in either grading or histotype of the tumors. In the IHC profiles, which included SRC3, Pax2, ER, PgR, Her2, CK5/6, Ki67, and EGFR, we found no statistically significant differences between the primary cancer and the brain metastasis. In our study of metastatic breast carcinoma deposits, there was no correlation between SRC3, Pax2 status and histotype, and tumor grade. The IHC status of the paired primary and metastatic deposits did not differ in a statistically significant manner.
dcterms:title
Expression of selected proteins in breast cancer brain metastases Expression of selected proteins in breast cancer brain metastases
skos:prefLabel
Expression of selected proteins in breast cancer brain metastases Expression of selected proteins in breast cancer brain metastases
skos:notation
RIV/00216208:11120/13:43907837!RIV14-MSM-11120___
n13:predkladatel
n14:orjk%3A11120
n3:aktivita
n16:S n16:I
n3:aktivity
I, S
n3:cisloPeriodika
3
n3:dodaniDat
n6:2014
n3:domaciTvurceVysledku
n4:6151388 n4:5995302 n4:5172497 n4:2630818 n4:8978182 n4:5398975 n4:1293354 n4:6750583 n4:1462024 n4:1637665 n4:7449186 n4:5144108
n3:druhVysledku
n17:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
74355
n3:idVysledku
RIV/00216208:11120/13:43907837
n3:jazykVysledku
n12:eng
n3:klicovaSlova
EGFR; Ki67; CK5/6; Her2; PgR; ER; Pax2; SRC3; immunohistochemistry; brain metastases; breast cancer
n3:klicoveSlovo
n8:CK5%2F6 n8:immunohistochemistry n8:breast%20cancer n8:brain%20metastases n8:PgR n8:ER n8:Her2 n8:EGFR n8:Pax2 n8:SRC3 n8:Ki67
n3:kodStatuVydavatele
PL - Polská republika
n3:kontrolniKodProRIV
[6B7D6BAE729E]
n3:nazevZdroje
Folia Histochemica et Cytobiologica
n3:obor
n9:FD
n3:pocetDomacichTvurcuVysledku
12
n3:pocetTvurcuVysledku
12
n3:rokUplatneniVysledku
n6:2013
n3:svazekPeriodika
51
n3:tvurceVysledku
Kubecová, Martina Rosina, Jozef Zmrhal, Jan Báča, Václav Báčová, Tereza Záhumenský, Jozef Mandys, Václav Frajerová, Denisa Vránová, Jana Čelko, Alexander Gojiš, Ondřej Kučera, Eduard
n3:wos
000327203300005
s:issn
0239-8508
s:numberOfPages
6
n5:doi
10.5603/FHC.2013.0030
n15:organizacniJednotka
11120