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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F13%3A43907372%21RIV14-MSM-11120___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Repeated bleeding in the joint cavities is the most annoying symptom and often has disabling effects in patients with hemophilia (PWH). Our aim was to study the effect of radiosynovectomy (RSO) with beta particle-emitting radiocolloids in the treatment of hemorhagic arthropathy. We have treated 22 joints from 18 patients with hemophilia A, from April 2008 to February 2012,5 knees, 11 elbows and 6 ankles. Joints were divided into two Groups, those treated with yttrium-90-citrate (Y-90-C) (5 knees, 2 of them twice)-Group I and those with rhenium-186-sulfide (Re-186-S) (11 elbows, 1 of them treated twice and 6 ankles)-Group II. A total of 25 treatments. Follow-up period was 3 months, 1 year and 3 years. Results showed a favourable subjective and a better objective result in all 5 joints of Group I and in 15/17 joints of Group II, respectively. Follow-up after 3 months showed significant improvement in Hemophilia Join Health Score (HJHS) after 20 treatments and steady score after 5 treatments. After 1 year, 19 treated joints had improved for the first time, 3 remained steady and 3 were not examined. After 3 years, 9 treated joints were HJHS steady, while 16 were not examined. One year after treatment, 13/14 joints of patients, aged 6-23 years showed better HJHS score, while 9/11 joints of patients aged 26-51 years, showed better HJHS. Synovial membrane thickness as measured by MRI in 8 joints, before and 3 months after treatment was not related to prognosis. In conclusion, in a small group of hemophilic patients with hemorrhagic arthropathy treated with Y-90-C and with Re-186-S, our study showed good results irrespective of age in 22/25 treatments after 3 months or 1 year. The thickness of synovial membrane in the 8 joints studied was not related to prognosis. Repeated bleeding in the joint cavities is the most annoying symptom and often has disabling effects in patients with hemophilia (PWH). Our aim was to study the effect of radiosynovectomy (RSO) with beta particle-emitting radiocolloids in the treatment of hemorhagic arthropathy. We have treated 22 joints from 18 patients with hemophilia A, from April 2008 to February 2012,5 knees, 11 elbows and 6 ankles. Joints were divided into two Groups, those treated with yttrium-90-citrate (Y-90-C) (5 knees, 2 of them twice)-Group I and those with rhenium-186-sulfide (Re-186-S) (11 elbows, 1 of them treated twice and 6 ankles)-Group II. A total of 25 treatments. Follow-up period was 3 months, 1 year and 3 years. Results showed a favourable subjective and a better objective result in all 5 joints of Group I and in 15/17 joints of Group II, respectively. Follow-up after 3 months showed significant improvement in Hemophilia Join Health Score (HJHS) after 20 treatments and steady score after 5 treatments. After 1 year, 19 treated joints had improved for the first time, 3 remained steady and 3 were not examined. After 3 years, 9 treated joints were HJHS steady, while 16 were not examined. One year after treatment, 13/14 joints of patients, aged 6-23 years showed better HJHS score, while 9/11 joints of patients aged 26-51 years, showed better HJHS. Synovial membrane thickness as measured by MRI in 8 joints, before and 3 months after treatment was not related to prognosis. In conclusion, in a small group of hemophilic patients with hemorrhagic arthropathy treated with Y-90-C and with Re-186-S, our study showed good results irrespective of age in 22/25 treatments after 3 months or 1 year. The thickness of synovial membrane in the 8 joints studied was not related to prognosis.
dcterms:title
Radiosynoviorthesis in hemophilic joints with yttrium-90 citrate and rhenium-186 sulfide and long term results Radiosynoviorthesis in hemophilic joints with yttrium-90 citrate and rhenium-186 sulfide and long term results
skos:prefLabel
Radiosynoviorthesis in hemophilic joints with yttrium-90 citrate and rhenium-186 sulfide and long term results Radiosynoviorthesis in hemophilic joints with yttrium-90 citrate and rhenium-186 sulfide and long term results
skos:notation
RIV/00216208:11120/13:43907372!RIV14-MSM-11120___
n7:predkladatel
n18:orjk%3A11120
n3:aktivita
n14:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n6:2014
n3:domaciTvurceVysledku
n10:1901265 n10:5704995 n10:9313605
n3:druhVysledku
n13:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
101365
n3:idVysledku
RIV/00216208:11120/13:43907372
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Clinical results; Rhenium; Yttrium; Haemophiliac arthropathy; Radiosynovectomy
n3:klicoveSlovo
n8:Haemophiliac%20arthropathy n8:Radiosynovectomy n8:Clinical%20results n8:Yttrium n8:Rhenium
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[55E147C82693]
n3:nazevZdroje
Hellenic Journal of Nuclear Medicine
n3:obor
n16:FP
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n6:2013
n3:svazekPeriodika
16
n3:tvurceVysledku
Teyssler, Petr Bobek, Vladimír Kološtová, Katarína
n3:wos
000317886400008
s:issn
1790-5427
s:numberOfPages
6
n15:organizacniJednotka
11120