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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F13%3A43907351%21RIV14-GA0-11120___
rdf:type
skos:Concept n4:Vysledek
dcterms:description
Aim: ATP-binding cassette (ABC) transporters contribute to development of resistance to anticancer drugs via ATP-dependent drug efflux. A major goal of our study was to investigate associations between the expression of ABC transporters and outcome of breast carcinoma patients. Patients & methods: Transcript levels of all 49 human ABC transporters were determined in post-treatment tumor and non-neoplastic tissue samples from 68 breast carcinoma patients treated by neoadjuvant chemotherapy. Six ABC transporters were then evaluated in independent series of 100 pretreatment patients. Results: ABCA5/6/8/9/10, ABCB1/5/11, ABCC6/9, ABCD2/4, ABCG5 and ABCG8 were significantly downregulated and ABCA2/3/7/12, ABCB2/3/8/9/10, ABCC1/4/5/10/11/12, ABCD1/3, ABCE1, ABCF1/2/3 and ABCG1 were upregulated in post-treatment tumors compared with non-neoplastic tissues. Significant associations of intratumoral levels of ABCC1 and ABCC8 with grade and expression of hormonal receptors were found in both sets of patients. ABCA12, ABCA13 and ABCD2 levels were significantly associated with the response to neoadjuvant chemotherapy in post-treatment patients. Protein expression of ABCA12, ABCC8 and ABCD2 in tumor tissues of patients with breast carcinoma was observed by immunoblotting for the first time. Conclusion: ABCA12, ABCA13, ABCC1, ABCC8 and ABCD2 present potential modifiers of progression and response to the chemotherapy of breast carcinoma. Aim: ATP-binding cassette (ABC) transporters contribute to development of resistance to anticancer drugs via ATP-dependent drug efflux. A major goal of our study was to investigate associations between the expression of ABC transporters and outcome of breast carcinoma patients. Patients & methods: Transcript levels of all 49 human ABC transporters were determined in post-treatment tumor and non-neoplastic tissue samples from 68 breast carcinoma patients treated by neoadjuvant chemotherapy. Six ABC transporters were then evaluated in independent series of 100 pretreatment patients. Results: ABCA5/6/8/9/10, ABCB1/5/11, ABCC6/9, ABCD2/4, ABCG5 and ABCG8 were significantly downregulated and ABCA2/3/7/12, ABCB2/3/8/9/10, ABCC1/4/5/10/11/12, ABCD1/3, ABCE1, ABCF1/2/3 and ABCG1 were upregulated in post-treatment tumors compared with non-neoplastic tissues. Significant associations of intratumoral levels of ABCC1 and ABCC8 with grade and expression of hormonal receptors were found in both sets of patients. ABCA12, ABCA13 and ABCD2 levels were significantly associated with the response to neoadjuvant chemotherapy in post-treatment patients. Protein expression of ABCA12, ABCC8 and ABCD2 in tumor tissues of patients with breast carcinoma was observed by immunoblotting for the first time. Conclusion: ABCA12, ABCA13, ABCC1, ABCC8 and ABCD2 present potential modifiers of progression and response to the chemotherapy of breast carcinoma.
dcterms:title
The expression profile of ATP-binding cassette transporter genes in breast carcinoma The expression profile of ATP-binding cassette transporter genes in breast carcinoma
skos:prefLabel
The expression profile of ATP-binding cassette transporter genes in breast carcinoma The expression profile of ATP-binding cassette transporter genes in breast carcinoma
skos:notation
RIV/00216208:11120/13:43907351!RIV14-GA0-11120___
n4:predkladatel
n5:orjk%3A11120
n6:aktivita
n9:S n9:P n9:I
n6:aktivity
I, P(GBP303/12/G163), P(NT13679), S
n6:cisloPeriodika
5
n6:dodaniDat
n13:2014
n6:domaciTvurceVysledku
n17:3956385 n17:3568946 n17:2977265
n6:druhVysledku
n11:J
n6:duvernostUdaju
n19:S
n6:entitaPredkladatele
n18:predkladatel
n6:idSjednocenehoVysledku
74359
n6:idVysledku
RIV/00216208:11120/13:43907351
n6:jazykVysledku
n15:eng
n6:klicovaSlova
response; resistance; prognosis; expression; breast carcinoma; ABC transporters
n6:klicoveSlovo
n14:expression n14:resistance n14:ABC%20transporters n14:response n14:breast%20carcinoma n14:prognosis
n6:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n6:kontrolniKodProRIV
[7D07D8163CB3]
n6:nazevZdroje
Pharmacogenomics
n6:obor
n12:EB
n6:pocetDomacichTvurcuVysledku
3
n6:pocetTvurcuVysledku
12
n6:projekt
n8:NT13679 n8:GBP303%2F12%2FG163
n6:rokUplatneniVysledku
n13:2013
n6:svazekPeriodika
14
n6:tvurceVysledku
Brynychová, Veronika Hlaváč, Viktor Kopperová, Dana
n6:wos
000317177700016
s:issn
1462-2416
s:numberOfPages
15
n7:organizacniJednotka
11120