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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F13%3A43907259%21RIV13-MSM-11120___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Multiple duodenal polyps are a relatively rare finding, usually co-occurrent with familial adenomatous polyposis (FAP).We report a patient with multiple duodenal adenomas and a negative examination for FAP: multiple flat polyps were detected endoscopically in a 37-year-old male patient, extending from the apex of the bulb to the end of the descending part of the duodenum. In terms of histology, they were tubular adenomas with moderate dysplasia. Colonoscopy and enteroclysis were normal. Both push and capsule enteroscopy only showed multiple polyps in the area of the descending duodenum. DNA analysis of the APC gene was as follows: DGGE, exon 1–15, deletion at codons 1309 and 1061 by means of PCR for attenuated APC were negative. Afterwards we screened the patient for germline MYH mutations using the denaturing high-performance liquid chromatography (DHPLC) in combination with sequencing. No novel pathogenic mutation has been identified. Large polyps were removed by means of endoscopic polypectomy and mucosectomy, while small polyps were removed by means of argon plasma coagulation.We conduct yearly checkups, removing only sporadic polyps. The rare finding of duodenal polyposis not co-occurrent with FAP proves that multiple adenomas in the digestive tube need not necessarily co-occur with FAP. Multiple duodenal polyps are a relatively rare finding, usually co-occurrent with familial adenomatous polyposis (FAP).We report a patient with multiple duodenal adenomas and a negative examination for FAP: multiple flat polyps were detected endoscopically in a 37-year-old male patient, extending from the apex of the bulb to the end of the descending part of the duodenum. In terms of histology, they were tubular adenomas with moderate dysplasia. Colonoscopy and enteroclysis were normal. Both push and capsule enteroscopy only showed multiple polyps in the area of the descending duodenum. DNA analysis of the APC gene was as follows: DGGE, exon 1–15, deletion at codons 1309 and 1061 by means of PCR for attenuated APC were negative. Afterwards we screened the patient for germline MYH mutations using the denaturing high-performance liquid chromatography (DHPLC) in combination with sequencing. No novel pathogenic mutation has been identified. Large polyps were removed by means of endoscopic polypectomy and mucosectomy, while small polyps were removed by means of argon plasma coagulation.We conduct yearly checkups, removing only sporadic polyps. The rare finding of duodenal polyposis not co-occurrent with FAP proves that multiple adenomas in the digestive tube need not necessarily co-occur with FAP.
dcterms:title
Multiple adenomatous duodenal polyposis Multiple adenomatous duodenal polyposis
skos:prefLabel
Multiple adenomatous duodenal polyposis Multiple adenomatous duodenal polyposis
skos:notation
RIV/00216208:11120/13:43907259!RIV13-MSM-11120___
n15:predkladatel
n16:orjk%3A11120
n3:aktivita
n11:I
n3:aktivity
I
n3:cisloPeriodika
Art. ID. 181704
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n4:9148167 n4:7449186 n4:6397743
n3:druhVysledku
n14:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
90131
n3:idVysledku
RIV/00216208:11120/13:43907259
n3:jazykVysledku
n13:eng
n3:klicovaSlova
case report; duodenal polyposis; Multiple adenomas
n3:klicoveSlovo
n5:duodenal%20polyposis n5:Multiple%20adenomas n5:case%20report
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[3053E6D93F14]
n3:nazevZdroje
Case Reports in Gastrointestinal Medicine (On-line)
n3:obor
n7:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n10:2013
n3:svazekPeriodika
2013
n3:tvurceVysledku
Mandys, Václav Hajer, Jan Zádorová, Zdeňka
s:issn
2090-6536
s:numberOfPages
3
n19:doi
10.1155/2013/181704
n6:organizacniJednotka
11120