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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F12%3A43909491%21RIV15-GA0-11120___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Cortical epileptic foci elicited by local application of bicuculline methiodide represent a model of interictal epileptic activity with a transition into ictal phases. We studied a role of GABA-B receptors in this model using GABA-B receptor antagonist CGP35348 in adult rats with implanted cortical electrodes and cannula. CGP35348 (100 or 200 mg/kg i.p.) did not affect interictal discharges but it augmented ictal activity. Latency to the first ictal episode was decreased by the lower dose of CGP35348, duration of episodes was increased by the higher dose. GABA-B receptor antagonist did not influence purely cortical epileptic phenomenon but it is proconvulsant in ictal activity generated with participation of subcortical structures. Cortical epileptic foci elicited by local application of bicuculline methiodide represent a model of interictal epileptic activity with a transition into ictal phases. We studied a role of GABA-B receptors in this model using GABA-B receptor antagonist CGP35348 in adult rats with implanted cortical electrodes and cannula. CGP35348 (100 or 200 mg/kg i.p.) did not affect interictal discharges but it augmented ictal activity. Latency to the first ictal episode was decreased by the lower dose of CGP35348, duration of episodes was increased by the higher dose. GABA-B receptor antagonist did not influence purely cortical epileptic phenomenon but it is proconvulsant in ictal activity generated with participation of subcortical structures.
dcterms:title
An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci
skos:prefLabel
An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci
skos:notation
RIV/00216208:11120/12:43909491!RIV15-GA0-11120___
n3:aktivita
n14:P n14:Z
n3:aktivity
P(GAP304/10/1274), P(LC554), Z(AV0Z50110509)
n3:cisloPeriodika
3
n3:dodaniDat
n19:2015
n3:domaciTvurceVysledku
n9:3935981
n3:druhVysledku
n12:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
121892
n3:idVysledku
RIV/00216208:11120/12:43909491
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Rat; Epileptic focus; CGP35348; Bicuculline; Cerebral cortex
n3:klicoveSlovo
n4:Cerebral%20cortex n4:Epileptic%20focus n4:Rat n4:Bicuculline n4:CGP35348
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[80815A61D7A7]
n3:nazevZdroje
Physiological Research
n3:obor
n18:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:projekt
n6:LC554 n6:GAP304%2F10%2F1274
n3:rokUplatneniVysledku
n19:2012
n3:svazekPeriodika
61
n3:tvurceVysledku
Bernášková, Klára
n3:wos
000306508000011
n3:zamer
n15:AV0Z50110509
s:issn
0862-8408
s:numberOfPages
5
n13:organizacniJednotka
11120