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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F12%3A43907368%21RIV14-MSM-11120___
rdf:type
skos:Concept n3:Vysledek
dcterms:description
The oronasal cavity in humans develops during embryonic day 30-60. There are three critical periods when this process can be affected, resulting in a specific type of orofacial cleft: cleft lip (CL), cleft palate (CP), or most serious, total cleft lip+palate (CLP). We assessed whether gestational bleeding during early pregnancy might act to produce a non-specific worsening of embryo status resulting in extension of the basic cleft type (CL or CP) into more serious CLP.Study design: In a group of the child patients with orofacial clefts, the cleft spectrum was correlated with first trimester gestational bleeding reported by the mother. Data were also related to the gender of patients, hereditary factors and additional malformations. Results: Among 2524 mothers who gave birth to babies with an orofacial cleft in the Czech Republic during 1983-2009, 253 (10.0%) had gestational bleeding. Among the children with an orofacial cleft, 497 (19.7%) had an orofacial cleft among relatives and 297 (11.8%) exhibited an additional congenital malformation. In comparison with mothers without bleeding, there was significant increase of children with CLP (p < 0.01) at the expense of children with CP, whose number significantly decreased (p < 0.01) in the bleeding mothers. In the group of children with clefts among relatives we did not find any significant change associated with bleeding. The maternal bleeding was more frequent in children with additional malformations, but this difference was not significant (p = 0.112). Conclusion: We hypothesize that size/extent and therefore seriousness of orofacial cleft might increase as a consequence of hypoxia resulting from gestational bleeding. The oronasal cavity in humans develops during embryonic day 30-60. There are three critical periods when this process can be affected, resulting in a specific type of orofacial cleft: cleft lip (CL), cleft palate (CP), or most serious, total cleft lip+palate (CLP). We assessed whether gestational bleeding during early pregnancy might act to produce a non-specific worsening of embryo status resulting in extension of the basic cleft type (CL or CP) into more serious CLP.Study design: In a group of the child patients with orofacial clefts, the cleft spectrum was correlated with first trimester gestational bleeding reported by the mother. Data were also related to the gender of patients, hereditary factors and additional malformations. Results: Among 2524 mothers who gave birth to babies with an orofacial cleft in the Czech Republic during 1983-2009, 253 (10.0%) had gestational bleeding. Among the children with an orofacial cleft, 497 (19.7%) had an orofacial cleft among relatives and 297 (11.8%) exhibited an additional congenital malformation. In comparison with mothers without bleeding, there was significant increase of children with CLP (p < 0.01) at the expense of children with CP, whose number significantly decreased (p < 0.01) in the bleeding mothers. In the group of children with clefts among relatives we did not find any significant change associated with bleeding. The maternal bleeding was more frequent in children with additional malformations, but this difference was not significant (p = 0.112). Conclusion: We hypothesize that size/extent and therefore seriousness of orofacial cleft might increase as a consequence of hypoxia resulting from gestational bleeding.
dcterms:title
Extension of orofacial cleft size and gestational bleeding in early pregnancy Extension of orofacial cleft size and gestational bleeding in early pregnancy
skos:prefLabel
Extension of orofacial cleft size and gestational bleeding in early pregnancy Extension of orofacial cleft size and gestational bleeding in early pregnancy
skos:notation
RIV/00216208:11120/12:43907368!RIV14-MSM-11120___
n3:predkladatel
n4:orjk%3A11120
n5:aktivita
n15:Z n15:I n15:P
n5:aktivity
I, P(NS10012), Z(AV0Z50390703)
n5:cisloPeriodika
2
n5:dodaniDat
n17:2014
n5:domaciTvurceVysledku
n16:3422283 n16:2580748 n16:3272532
n5:druhVysledku
n19:J
n5:duvernostUdaju
n11:S
n5:entitaPredkladatele
n6:predkladatel
n5:idSjednocenehoVysledku
135909
n5:idVysledku
RIV/00216208:11120/12:43907368
n5:jazykVysledku
n20:eng
n5:klicovaSlova
birth defect; cleft lip and palate; malformation; pregnancy; early human development
n5:klicoveSlovo
n8:pregnancy n8:early%20human%20development n8:malformation n8:cleft%20lip%20and%20palate n8:birth%20defect
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[F41921AA8261]
n5:nazevZdroje
Acta Chirurgiae Plasticae
n5:obor
n12:FJ
n5:pocetDomacichTvurcuVysledku
3
n5:pocetTvurcuVysledku
8
n5:projekt
n9:NS10012
n5:rokUplatneniVysledku
n17:2012
n5:svazekPeriodika
54
n5:tvurceVysledku
Borský, Jiří Panczak, Aleš Tvrdek, Miroslav
n5:zamer
n18:AV0Z50390703
s:issn
0001-5423
s:numberOfPages
6
n14:organizacniJednotka
11120