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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F12%3A43907054%21RIV13-MZ0-11120___
rdf:type
n15:Vysledek skos:Concept
rdfs:seeAlso
http://pmr.cuni.cz/file/5629/PMR2012A0019.pdf
dcterms:description
The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA- or saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg), cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was examined in Laboras, nociception in Plantar test, and active drug-seeking behavior in conditioned place preference (CPP). Our data demonstrate that cocaine increased the exploratory activity in Laboras test in prenatally saline-exposed, but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was demonstrated only by the tail withdrawal and it was independent of the prenatal drug exposure. CPP test showed that prenatal MA exposure induced rather tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats, and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar test, the results demonstrated that morphine had an analgesic effect in prenatally saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats. In the CPP test morphine induced drug-seeking behavior, which however was not affected by prenatal drug exposure. Thus, our data demonstrate that there is a cross-effect between prenatal MA exposure and the challenge dose of other drug in adulthood, however drug-seeking behavior is not increased by prenatal MA exposure as we expected. The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA- or saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg), cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was examined in Laboras, nociception in Plantar test, and active drug-seeking behavior in conditioned place preference (CPP). Our data demonstrate that cocaine increased the exploratory activity in Laboras test in prenatally saline-exposed, but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was demonstrated only by the tail withdrawal and it was independent of the prenatal drug exposure. CPP test showed that prenatal MA exposure induced rather tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats, and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar test, the results demonstrated that morphine had an analgesic effect in prenatally saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats. In the CPP test morphine induced drug-seeking behavior, which however was not affected by prenatal drug exposure. Thus, our data demonstrate that there is a cross-effect between prenatal MA exposure and the challenge dose of other drug in adulthood, however drug-seeking behavior is not increased by prenatal MA exposure as we expected.
dcterms:title
Does prenatal methamphetamine exposure induce cross-sensitization to cocaine and morphine in adult male rats? Does prenatal methamphetamine exposure induce cross-sensitization to cocaine and morphine in adult male rats?
skos:prefLabel
Does prenatal methamphetamine exposure induce cross-sensitization to cocaine and morphine in adult male rats? Does prenatal methamphetamine exposure induce cross-sensitization to cocaine and morphine in adult male rats?
skos:notation
RIV/00216208:11120/12:43907054!RIV13-MZ0-11120___
n15:predkladatel
n19:orjk%3A11120
n3:aktivita
n4:S n4:P
n3:aktivity
P(GA305/09/0126), P(NS10509), S
n3:cisloPeriodika
3
n3:dodaniDat
n6:2013
n3:domaciTvurceVysledku
n11:1027980 n11:6877141 n11:4711491 n11:6103316 n11:6841910 n11:1128574 n11:6894577 n11:4987063
n3:druhVysledku
n18:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
131851
n3:idVysledku
RIV/00216208:11120/12:43907054
n3:jazykVysledku
n9:eng
n3:klicovaSlova
drug-seeking behavior; nociception; locomotion; Conditioned place preference; Plantar test; Open field; morphine; cocaine; methamphetamine; prenatal drug exposure
n3:klicoveSlovo
n10:Conditioned%20place%20preference n10:locomotion n10:Open%20field n10:Plantar%20test n10:drug-seeking%20behavior n10:methamphetamine n10:cocaine n10:nociception n10:morphine n10:prenatal%20drug%20exposure
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[6361A1929472]
n3:nazevZdroje
Prague Medical Report
n3:obor
n13:FH
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
8
n3:projekt
n14:GA305%2F09%2F0126 n14:NS10509
n3:rokUplatneniVysledku
n6:2012
n3:svazekPeriodika
113
n3:tvurceVysledku
Nohejlová-Deykun, Kateryna Hrubá, Lenka Macúchová, Eva Yamamotová, Anna Pometlová, Marie Šlamberová, Romana Nová, Eva Schutová, Barbora
s:issn
1214-6994
s:numberOfPages
17
n8:organizacniJednotka
11120