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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F12%3A43905458%21RIV13-MSM-11120___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Hypoadiponectinemia observed in obesity is associated with insulin resistance, diabetes and atherosclerosis. The aim of the present study was to investigate secretion of adiponectin and its multimeric isoforms by explants derived from subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in obese and non-obese subjects.Design:Paired samples of SAT and VAT and blood samples were obtained from 23 subjects (10 non-obese and 13 obese) undergoing elective abdominal surgery. Total adiponectin quantities and adiponectin isoforms were measured in conditioned media of explants derived from SAT and VAT using enzyme-linked immunosorbent assay and non-denaturing western blot, respectively.Results:Total adiponectin plasma levels were lower in obese than in non-obese subjects (P<0.05). Secretion of total adiponectin in adipose tissue (AT) explants was lower in obese than in non-obese subjects in SAT (P<0.05) but not in VAT. In both, SAT and VAT, the most abundant isoform released into conditioned media was the high-molecular weight (HMW) form. Its relative proportion in relation to total adiponectin was higher in conditioned media of explants from both fat depots when compared with plasma (P<0.001). The proportion of secreted HMW vs total adiponectin was higher in VAT than in SAT explants in the group of non-obese individuals (49.3-3.1% in VAT vs 40.6-2.8% in SAT; P<0.01), whereas no difference between the two depots was found in obese subjects (46.2-3.0 % in VAT vs 46.0-2.4 % in SAT).Conclusion:Obesity is associated with the decrease of total adiponectin secretion in SAT. The profile of adiponectin isoforms secreted by SAT and VAT explants differs from that in plasma. Secretion of total adiponectin and HMW isoform of adiponectin are different in obese and non-obese subjects in relation to AT depot. Hypoadiponectinemia observed in obesity is associated with insulin resistance, diabetes and atherosclerosis. The aim of the present study was to investigate secretion of adiponectin and its multimeric isoforms by explants derived from subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in obese and non-obese subjects.Design:Paired samples of SAT and VAT and blood samples were obtained from 23 subjects (10 non-obese and 13 obese) undergoing elective abdominal surgery. Total adiponectin quantities and adiponectin isoforms were measured in conditioned media of explants derived from SAT and VAT using enzyme-linked immunosorbent assay and non-denaturing western blot, respectively.Results:Total adiponectin plasma levels were lower in obese than in non-obese subjects (P<0.05). Secretion of total adiponectin in adipose tissue (AT) explants was lower in obese than in non-obese subjects in SAT (P<0.05) but not in VAT. In both, SAT and VAT, the most abundant isoform released into conditioned media was the high-molecular weight (HMW) form. Its relative proportion in relation to total adiponectin was higher in conditioned media of explants from both fat depots when compared with plasma (P<0.001). The proportion of secreted HMW vs total adiponectin was higher in VAT than in SAT explants in the group of non-obese individuals (49.3-3.1% in VAT vs 40.6-2.8% in SAT; P<0.01), whereas no difference between the two depots was found in obese subjects (46.2-3.0 % in VAT vs 46.0-2.4 % in SAT).Conclusion:Obesity is associated with the decrease of total adiponectin secretion in SAT. The profile of adiponectin isoforms secreted by SAT and VAT explants differs from that in plasma. Secretion of total adiponectin and HMW isoform of adiponectin are different in obese and non-obese subjects in relation to AT depot.
dcterms:title
The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue
skos:prefLabel
The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue
skos:notation
RIV/00216208:11120/12:43905458!RIV13-MSM-11120___
n10:predkladatel
n20:orjk%3A11120
n3:aktivita
n17:S n17:Z
n3:aktivity
S, Z(MSM0021620814)
n3:cisloPeriodika
10
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n9:4377974 n9:3966577 n9:8835659 n9:6395996 n9:2809508 n9:9021000
n3:druhVysledku
n14:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
140666
n3:idVysledku
RIV/00216208:11120/12:43905458
n3:jazykVysledku
n15:eng
n3:klicovaSlova
adipose tissue; body fat distribution; adiponectin
n3:klicoveSlovo
n18:adiponectin n18:adipose%20tissue n18:body%20fat%20distribution
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[5EB78A4F3375]
n3:nazevZdroje
International Journal of Obesity
n3:obor
n13:FB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n5:2012
n3:svazekPeriodika
36
n3:tvurceVysledku
Rossmeislová, Lenka Kováčová, Zuzana Wedellová, Zuzana Štich, Vladimír Polák, Jan Tencerová, Michaela
n3:wos
000309649400017
n3:zamer
n16:MSM0021620814
s:issn
0307-0565
s:numberOfPages
6
n11:doi
10.1038/ijo.2011.223
n19:organizacniJednotka
11120