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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F12%3A43903694%21RIV13-MZ0-11120___
rdf:type
n4:Vysledek skos:Concept
rdfs:seeAlso
http://www.csnn.eu/ceska-slovenska-neurologie-clanek/tau-protein-a-anti-tau-protilatky-u-pacientu-s-roztrousenou-sklerozou-38120?confirm_rules=1
dcterms:description
Background: Neuronal damage in multiple sclerosis (MS) may be associated with the release of cytoskeletal tau protein. This antigen interacts with dysregulated immune system and this results in anti-tau antibody synthesis. Tau-protein concentrations and anti-tau antibody levels in cerebrospinal fluid (CSF) and in serum may correlate. Methods: Total tau protein and anti- -tau antibodies measured using ELISA methods were studied in 31 patients (14 MS patients and 17 neurological controls). We calculated three ratios: the CSF tau concentration to a) the CSF anti-tau antibody level, b) the serum anti-tau antibody concentration and c) the level of intrathecal anti-tau antibodies. Results: We did not find any significant correlation between the tau protein concentrations and anti-tau antibody levels (serum, CSF or intrathecal) in the MS group or in the controls. There was no difference in the CSF tau concentrations or any of the calculated ratios between MS patients and controls. Conclusions: The release of tau protein into CSF and anti-tau humoral response are independent processes in MS and do not differentiate the MS patients from other neurological patients. Background: Neuronal damage in multiple sclerosis (MS) may be associated with the release of cytoskeletal tau protein. This antigen interacts with dysregulated immune system and this results in anti-tau antibody synthesis. Tau-protein concentrations and anti-tau antibody levels in cerebrospinal fluid (CSF) and in serum may correlate. Methods: Total tau protein and anti- -tau antibodies measured using ELISA methods were studied in 31 patients (14 MS patients and 17 neurological controls). We calculated three ratios: the CSF tau concentration to a) the CSF anti-tau antibody level, b) the serum anti-tau antibody concentration and c) the level of intrathecal anti-tau antibodies. Results: We did not find any significant correlation between the tau protein concentrations and anti-tau antibody levels (serum, CSF or intrathecal) in the MS group or in the controls. There was no difference in the CSF tau concentrations or any of the calculated ratios between MS patients and controls. Conclusions: The release of tau protein into CSF and anti-tau humoral response are independent processes in MS and do not differentiate the MS patients from other neurological patients.
dcterms:title
Tau protein and anti-tau antibodies in patients with multiple sclerosis Tau protein and anti-tau antibodies in patients with multiple sclerosis
skos:prefLabel
Tau protein and anti-tau antibodies in patients with multiple sclerosis Tau protein and anti-tau antibodies in patients with multiple sclerosis
skos:notation
RIV/00216208:11120/12:43903694!RIV13-MZ0-11120___
n4:predkladatel
n11:orjk%3A11120
n3:aktivita
n16:P n16:I
n3:aktivity
I, P(NS10369)
n3:cisloPeriodika
3
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n6:1787977
n3:druhVysledku
n12:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
173278
n3:idVysledku
RIV/00216208:11120/12:43903694
n3:jazykVysledku
n10:eng
n3:klicovaSlova
multiple sclerosis; cerebro­spinal fluid; autoantibodies; tau protein
n3:klicoveSlovo
n8:cerebro%C2%ADspinal%20fluid n8:tau%20protein n8:autoantibodies n8:multiple%20sclerosis
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[CF2014EA1A69]
n3:nazevZdroje
Česká a slovenská neurologie a neurochirurgie
n3:obor
n20:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n15:NS10369
n3:rokUplatneniVysledku
n5:2012
n3:svazekPeriodika
75
n3:tvurceVysledku
Fialová, Lenka Bartoš, Aleš
n3:wos
000305819900006
s:issn
1210-7859
s:numberOfPages
4
n17:organizacniJednotka
11120