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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F12%3A43903600%21RIV13-MZ0-11120___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://iv.iiarjournals.org/content/26/3/473.abstract
dcterms:description
Aim: Comparison of DNA ploidy status of different tumour tissue samples (fresh/frozen vs. paraffin-embedded; curettage vs. hysterectomy samples) obtained during diagnosis and treatment of patients with endometrial carcinoma. Patients and Methods: DNA ploidy status and conventional prognostic parameters were recorded for 74 patients with endometrial carcinoma prospectively. Results: In 59 (79.7%) patients the DNA status was described as diploid in all analyzed tissue samples. The remaining 15 (20.3%) cases were described as DNA aneuploid in at least one of the corresponding tissue samples. The concordance between DNA ploidy status in fresh vs. paraffin-embedded hysterectomy samples as well as curettage vs. hysterectomy paraffin-embedded samples was high (kappa coefficient κ=0.6348, 95% confidence interval CI=0.3673-0.9023, and p=0.6408, 95% CI=0.3977-0.8838), however, the methods are not interchangeable. Conclusion: The DNA ploidy discordance observed in our study group seems to document intratumoral heterogeneity that should be expected when applying DNA ploidy status in the clinical management of endometrial carcinoma. Aim: Comparison of DNA ploidy status of different tumour tissue samples (fresh/frozen vs. paraffin-embedded; curettage vs. hysterectomy samples) obtained during diagnosis and treatment of patients with endometrial carcinoma. Patients and Methods: DNA ploidy status and conventional prognostic parameters were recorded for 74 patients with endometrial carcinoma prospectively. Results: In 59 (79.7%) patients the DNA status was described as diploid in all analyzed tissue samples. The remaining 15 (20.3%) cases were described as DNA aneuploid in at least one of the corresponding tissue samples. The concordance between DNA ploidy status in fresh vs. paraffin-embedded hysterectomy samples as well as curettage vs. hysterectomy paraffin-embedded samples was high (kappa coefficient κ=0.6348, 95% confidence interval CI=0.3673-0.9023, and p=0.6408, 95% CI=0.3977-0.8838), however, the methods are not interchangeable. Conclusion: The DNA ploidy discordance observed in our study group seems to document intratumoral heterogeneity that should be expected when applying DNA ploidy status in the clinical management of endometrial carcinoma.
dcterms:title
Heterogeneity of DNA Ploidy in Endometrial Carcinoma: Comparison of Different Tissue Samples Obtained during Diagnosis and Treatment Heterogeneity of DNA Ploidy in Endometrial Carcinoma: Comparison of Different Tissue Samples Obtained during Diagnosis and Treatment
skos:prefLabel
Heterogeneity of DNA Ploidy in Endometrial Carcinoma: Comparison of Different Tissue Samples Obtained during Diagnosis and Treatment Heterogeneity of DNA Ploidy in Endometrial Carcinoma: Comparison of Different Tissue Samples Obtained during Diagnosis and Treatment
skos:notation
RIV/00216208:11120/12:43903600!RIV13-MZ0-11120___
n10:predkladatel
n12:orjk%3A11120
n3:aktivita
n14:P
n3:aktivity
P(NS9975)
n3:cisloPeriodika
3
n3:dodaniDat
n13:2013
n3:domaciTvurceVysledku
n8:7503024 n8:5704995 n8:8814821 n8:9313605 n8:2394685 n8:8978182 n8:7916396 n8:2483327 n8:9176586 n8:8675007
n3:druhVysledku
n15:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
138866
n3:idVysledku
RIV/00216208:11120/12:43903600
n3:jazykVysledku
n11:eng
n3:klicovaSlova
flow cytometry; endometrial carcinoma; heterogeneity; DNA ploidy
n3:klicoveSlovo
n4:endometrial%20carcinoma n4:heterogeneity n4:flow%20cytometry n4:DNA%20ploidy
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[C648D215D726]
n3:nazevZdroje
In Vivo
n3:obor
n17:FD
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
11
n3:projekt
n20:NS9975
n3:rokUplatneniVysledku
n13:2012
n3:svazekPeriodika
26
n3:tvurceVysledku
Pintérová, Daniela Tikovský, Karel Hubičková Heringová, Lucie Kološtová, Katarína Líbalová, Pavla Svoboda, Bohuslav Kubecová, Martina Housa, Daniel Vernerová, Zdeňka Bobek, Vladimír
n3:wos
000303351100018
s:issn
0258-851X
s:numberOfPages
8
n19:organizacniJednotka
11120